HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.

人类粒细胞埃里希体病：美国中北部

• 批准号: 6497381
• 负责人: RUSSELL C JOHNSON
• 金额: $ 36.59万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6497381
• 关键词: Carnivora; Ixodes; Rodentias; Ungulate; United States; arthropod borne communicable disease; communicable disease transmission; disease reservoirs; dogs; ehrlichiosis; emerging infectious disease; epizootiology; geographic site; human tissue; polymerase chain reaction; public health; restriction fragment length polymorphism; serology /serodiagnosis; tissue /cell culture; western blottings

DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness. The agent of HGE is closely related to or identical to the horse pathogen Ehrlichia equi and is transmitted by Ixodes scapularis, the same tick that transmits the agents of Lyme disease and babesiosis. The HGE agent infects blood polymorphonuclear neutrophils resulting in neutropenia and a thrombocytopenia. HGE may be a mild to potentially fatal disease. HGE was first described in Minnesota and Wisconsin in 1994 and subsequently more than 400 cases have been described in the U.S. In contrast to Lyme disease which frequently occurs in children, the rates and severity of HGE increase with age. This age-specific incidence of HGE and our large aging population presents a potentially major public health problem with corresponding economic consequences. This emerging public health problem highlights the importance of early diagnosis and treatment in preventing complications of infection, and targeting of prevention and control studies to populations at highest risk. The research proposed in this application is designed to aid in achieving the above goals by analyzing the epizootiology of HGE in the North Central U.S. Our specific aims are: to investigate the hypothesis that white-tailed deer serve as a large mammal reservoir of the agent of HGE and to identify the small mammal reservoirs of the HGE agent.

描述：人粒细胞埃利希体病 (HGE) 是一种新兴的蜱传病毒 急性发热性疾病。 HGE 的作用与以下密切相关或相同： 马病原体马埃利希体，由肩胛硬蜱传播 传播莱姆病和巴贝斯虫病的同一种蜱虫。人类基因组 病原体感染血液中的多形核中性粒细胞，导致中性粒细胞减少症 血小板减少症。 HGE 可能是一种轻微甚至可能致命的疾病。 HGE 是 1994 年首次在明尼苏达州和威斯康星州被描述，随后超过 美国已描述了 400 例病例，与莱姆病形成鲜明对比的是，莱姆病 HGE 常见于儿童，其发生率和严重程度随着年龄的增长而增加。 HGE 的特定年龄发病率和我们庞大的老龄化人口呈现出 潜在的重大公共卫生问题以及相应的经济问题 结果。这一新出现的公共卫生问题凸显了以下问题的重要性： 早期诊断和治疗以预防感染并发症，以及 针对最高风险人群进行预防和控制研究。这 本申请中提出的研究旨在帮助实现上述目标 通过分析美国中北部 HGE 的流行病学来实现我们的目标 具体目标是：调查白尾鹿服务的假设 作为 HGE 制剂的大型哺乳动物储存库并识别小型 HGE 剂的哺乳动物储存库。