COGNITIVE EVENT-RELATED POTENTIALS IN ADHD AND STIMULANT TREATMENT

ADHD 和兴奋剂治疗中认知事件相关的潜力

• 批准号: 6395935
• 负责人: RAFAEL KLORMAN KLORMAN
• 金额: $ 26.88万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6395935
• 关键词: adolescence (12-20); attention; attention deficit disorder; auditory stimulus; behavioral /social science research tag; child (0-11); clinical research; cognition; comorbidity; emotions; evoked potentials; gender difference; human subject; human therapy evaluation; mental disorder chemotherapy; methylphenidate; neural information processing; reading disorder; speech; stimulant /agonist; visual stimulus

We propose to study event-related potential: (ERPS) and performance measures to delineate attentional dysfunction in Attention-deficit Hyperactivity Disorder (ADHD) adolescents. We will explore the extent of differences in the prevalence of deficits in processing varying degrees of cognitive load and demands of selective attention among ADHD patients identified in childhood a: having ADHD with hyperactivity as well as inattentiveness (ADHD/Combined Type), ADHD without hyperactivity (ADHD/Inattentive Type), ADHD/Combined Type with reading disorder (RD) ADHD/Inattentive Type with (RD), and RD without ADHD. Male: and files in each group will be sampled in sufficient numbers in order to examine hitherto neglected sex differences. In order to evaluate the differential impact of pharmacological therapy on these clinical populations we will study all these subjects in a double-blind challenge with methylphenidate (0.5 mg/Kg) and placebo. This research will provide information on the extent of impact of stimulants on attentional function among various forms of the ADHD syndrome. We will also test normal adolescents without medication, so that we can determine the extent to which the ADHD and RD samples attentional functions are normal.

我们建议研究与事件相关的潜力：（ERP）和性能 划定注意力缺陷的注意力障碍的措施 多动症（ADHD）青少年。 我们将探索 处理不同程度的不足患病率的差异 多动症患者的认知负荷和选择性注意的需求 在儿童时期识别：多动症和多动症和多动症 不专心（ADHD/组合类型），无动于多的ADHD （多动症/注意力不集中），ADHD/联合型与阅读障碍（RD） ADHD/与（RD）的不集中类型，并且无多动症的RD。 男性：和文件 每个组都将以足够的数量进行采样以检查 迄今为止忽略了性别差异。 为了评估差异 药理治疗对这些临床人群的影响我们将 在用哌醋甲酯的双盲挑战中研究所有这些受试者 （0.5 mg/kg）和安慰剂。 这项研究将提供有关 兴奋剂对各种形式注意力功能的影响程度 多动症综合征。 我们还将测试普通青少年没有 用药，以便我们可以确定多动症和RD的程度 样本注意功能是正常的。