COGNITIVE EVENT-RELATED POTENTIALS IN ADHD AND STIMULANT TREATMENT

ADHD 和兴奋剂治疗中认知事件相关的潜力

• 批准号: 6108526
• 负责人: RAFAEL KLORMAN KLORMAN
• 金额: $ 26.88万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6108526
• 关键词: adolescence (12-20); attention; attention deficit disorder; auditory stimulus; behavioral /social science research tag; child (0-11); clinical research; cognition; comorbidity; emotions; evoked potentials; gender difference; human subject; human therapy evaluation; mental disorder chemotherapy; methylphenidate; neural information processing; reading disorder; speech; stimulant /agonist; visual stimulus

We propose to study event-related potential: (ERPS) and performance measures to delineate attentional dysfunction in Attention-deficit Hyperactivity Disorder (ADHD) adolescents. We will explore the extent of differences in the prevalence of deficits in processing varying degrees of cognitive load and demands of selective attention among ADHD patients identified in childhood a: having ADHD with hyperactivity as well as inattentiveness (ADHD/Combined Type), ADHD without hyperactivity (ADHD/Inattentive Type), ADHD/Combined Type with reading disorder (RD) ADHD/Inattentive Type with (RD), and RD without ADHD. Male: and files in each group will be sampled in sufficient numbers in order to examine hitherto neglected sex differences. In order to evaluate the differential impact of pharmacological therapy on these clinical populations we will study all these subjects in a double-blind challenge with methylphenidate (0.5 mg/Kg) and placebo. This research will provide information on the extent of impact of stimulants on attentional function among various forms of the ADHD syndrome. We will also test normal adolescents without medication, so that we can determine the extent to which the ADHD and RD samples attentional functions are normal.

我们建议研究事件相关潜力：（ERPS）和绩效 描述注意力缺陷患者注意力功能障碍的措施 多动症（ADHD）青少年。 我们将探讨的范围 处理不同程度的缺陷的普遍性存在差异 ADHD 患者的认知负荷和选择性注意需求 在童年时期就发现了a：患有注意力缺陷多动症（ADHD）并伴有多动症 注意力不集中（ADHD/混合型）、ADHD 不伴有多动症 （注意力缺陷多动症/注意力不集中型）、注意力缺陷多动症/阅读障碍合并型（RD） ADHD/注意力不集中型 (RD) 和 RD 无 ADHD。 男：和档案中 每组都将进行足够数量的抽样，以便检查 迄今为止，性别差异被忽视了。 为了评估差异 药物治疗对这些临床人群的影响，我们将 在哌醋甲酯的双盲挑战中研究所有这些受试者 （0.5 毫克/公斤）和安慰剂。 这项研究将提供有关 兴奋剂对不同形式注意力功能的影响程度 多动症综合症。 我们还将测试正常青少年，而无需 药物治疗，以便我们可以确定 ADHD 和 RD 的程度 样本注意功能正常。