BRAIN MORPHOMETRY IN READING-DISABLED TWINS

阅读障碍双胞胎的大脑形态分析

• 批准号: 6301963
• 负责人: BRUCE F PENNINGTON
• 金额: $ 18.18万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301963
• 关键词: adolescence (12-20); behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; cerebral cortex; child mental disorders; clinical research; human subject; magnetic resonance imaging; middle childhood (6-11); neuroanatomy; psycholinguistics; reading disorder; twin /multiplet

The overall goal of the proposed research is to test for genetic and environmental influences on brain structure in reading disability (RD) by performing morphometric analyses of MRI scans collected from RD and non-RD twin pairs. The specific goals of the proposed research are: 1.) To collect MRI scans from 20 twin pairs a year. When combined with the current sample, this will result in a total sample of 80 monozygotic (MZ) and 80 dizygotic (DZ) pairs in which at least one member of each pair will be reading disabled (RD) and 20 DZ pairs in which neither member will be RD. 2.) To perform state-of-the-art morphometric analyses, including cortical parcellation analyses, of these MRI scans targeting structures previously implicated in RD. These morphometric analyses will be performed without knowledge of subjects' diagnosis, relation, or zygosity. 3.) To conduct multivariate behavior genetic analyses of a.) the genetic and environmental components of variation in these morphometric measures and b.) their phenotypic and etiologic relations with behavioral measures. These analyses will be both confirmatory - by testing current strong hypotheses about brain-behavior relations in RD - and exploratory. 4.) To test whether the gene (s) influencing RD also influence brain structures which differentiate individuals with RD from controls. These analyses will use the methods in Research Project 4. 5.) To address basic issues in the new field of in vivo measurement of brain morphometry, such as relations among various brain structures and their relations to external variables, such as sex, age, and cognitive abilities.

拟议研究的总体目标是测试遗传和 环境对阅读障碍（RD）中大脑结构的影响 对从RD和非RD收集的MRI扫描进行形态计算分析 双子对。 拟议研究的具体目标是： 1.）每年从20对双胞胎收集MRI扫描。 合并时 当前样本，这将导致总样本为80个单卵 （MZ）和80个双粘合（DZ）对，其中至少一个成员 将被读取障碍（RD）和20 dz对 成为RD。 2.）进行最新的形态计量学分析，包括皮质 这些MRI扫描以前针对结构的分析分析 与Rd有关。 这些形态计量分析将在没有的情况下进行 了解受试者的诊断，关系或合影。 3.）进行a的多元行为遗传分析。）遗传 这些形态计量测量中变化的环境成分 b。）他们与行为措施的表型和病因关系。 这些分析都将是确认性的 - 通过测试电流强 关于RD和探索性脑行为关系的假设。 4.）测试基因是否影响RD也会影响大脑 将RD与对照区分开的结构。 这些 分析将使用研究项目4中的方法。 5.）解决新的体内测量领域的基本问题 大脑形态计量学，例如各种大脑结构之间的关系 它们与外部变量（例如性别，年龄和认知）的关系 能力。