ADHD AND EXECUTIVE FUNCTIONS--RELATION TO LEARNING DISABILITIES

ADHD 和执行功能——与学习障碍的关系

• 批准号: 6301960
• 负责人: BRUCE F PENNINGTON
• 金额: $ 18.18万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301960
• 关键词: Turner's syndrome; adolescence (12-20); attention deficit disorder; behavioral /social science research tag; clinical research; comorbidity; family genetics; female; fragile X syndromes; genetic disorder diagnosis; human subject; interview; learning disorders; medical complication; middle childhood (6-11); neurofibromatosis; neuropsychological tests; phenylketonurias; psychomotor function; reading disorder; statistics /biometry; twin /multiplet

The overall goal of the proposed research is to use converging methods to better understand the causal relation between RD and its psychiatric correlates particularly ADHD. The specific goals of the proposed research are: 1. To administer measures of attention deficit hyperactivity disorder (ADHD) and executive functions (EFs) to three different populations; a) 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair is reading disabled (RD); b) an independent sample of 50 pairs of MZ and 50 pairs of DZ twins in which at least one member of each pair manifests symptoms of ADHD; and c) a comparison group of 50 pairs of MZ and 50 pairs of DZ twins with no school history of learning disabilities (LDs) or ADHD. 2. To perform a genetic linkage study to identify one or more quantitative trait loci (QTLs) influencing ADHD. 3. To test competing explanations for the association between RD and ADHD using genetic and neuropsychological analyses. 4. To examine the rates and etiology of other psychiatric correlates of RD and ADHD.

拟议研究的总体目标是将融合方法使用 更好地了解RD与其精神病之间的因果关系 特别是多动症。 拟议研究的具体目标 是： 1。采用注意力缺陷多动症的措施 （ADHD）和执行职能（EFS）到三个不同的人群； 一个） 50对MZ和50对DZ双胞胎，其中至少一个成员 每对读取禁用（RD）； b）独立样本的50对 MZ和50对DZ双胞胎，其中至少一个成员 表现出多动症的症状； c）一个比较组，由50对MZ和 50双DZ双胞胎，没有学校学习障碍历史（LDS） 或多动症。 2。进行遗传连锁研究以识别一个或多个定量 特质基因座（QTLS）影响多动症。 3。测试RD和ADHD之间关联的竞争解释 使用遗传和神经心理学分析。 4。检查RD其他精神病学的速度和病因 和多动症。