VALIDITY OF SUBTYPES OF ADHD

ADHD 亚型的有效性

• 批准号: 6564688
• 负责人: BRUCE F PENNINGTON
• 金额: $ 19.74万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6564688
• 关键词: adolescence (12-20); age difference; attention deficit disorder; behavioral /social science research tag; behavioral genetics; child psychology; clinical research; cognition; comorbidity; comprehension; diagnosis design /evaluation; disease /disorder classification; disease /disorder etiology; family genetics; family structure /dynamics; gender difference; human subject; linkage mapping; middle childhood (6-11); neuropsychological tests; questionnaires; reading disorder; statistics /biometry; twin /multiplet; adolescence (12-20); age difference; attention deficit disorder; behavioral /social science research tag; behavioral genetics; child psychology; clinical research; cognition; comorbidity; comprehension; diagnosis design /evaluation; disease /disorder classification; disease /disorder etiology; family genetics; family structure /dynamics; gender difference; human subject; linkage mapping; middle childhood (6-11); neuropsychological tests; questionnaires; reading disorder; statistics /biometry; twin /multiplet

The overall goal of the proposed research is to test the internal and external validity of subtypes of ADHD using converging methods. To accomplish these objectives as part of our ongoing study, we will administer a batter of neuropsychological and psychiatric measures to samples of RD, ADHD, and control twin pairs (50 MZ and 50 DZ pairs in each group) and their siblings. The reliability and internal validity of the ADHD subtypes will be tested by examining inter-rater agreement and test-retest reliability and conducting factor and cluster analyses of individual symptoms. Diagnostic and discriminant validity of the subtypes will be tested by comparing subtypes on measures of functional impairment and other clinical correlates. Etiological relations among the subtypes will be tested using multiple regression analyses of twin data and molecular genetic linkage and association methods, and the cognitive relations among the subtypes will be tested with neuropsychological measures. The neuropsychological battery is designed to test further the executive deficit hypotheses of ADHD by pitting it against competing hypotheses that suggest ADHD is attributable to a deficit in motivation, arousal regulation, or response modulation.

拟议研究的总体目标是使用收敛方法测试ADHD亚型的内部和外部有效性。为了作为我们正在进行的研究的一部分实现这些目标，我们将对RD，ADHD和对照双胞胎的样本（每组中的50 mz和50 dz对）及其兄弟姐妹进行神经心理学和精神病学措施的面糊。 ADHD子类型的可靠性和内部有效性将通过检查评估者一致性，测试可靠性以及导电因素以及个体症状的群集分析来测试。亚型的诊断和判别有效性将通过比较功能障碍和其他临床相关性的亚型来测试。亚型之间的病因关系将使用双数据和分子遗传链接和关联方法的多个回归分析进行测试，并且亚型之间的认知关系将通过神经心理学指标进行测试。神经心理电池旨在通过将ADHD与竞争假设相抗衡，以进一步检验ADHD的执行缺陷假设，这些假设表明ADHD归因于动机，唤醒调节或反应调制的赤字。