DUAL OLFACTORY SYSTEM--STRUCTURE/FUNCTION

双嗅觉系统——结构/功能

• 批准号: 6342349
• 负责人: MIMI N. HALPERN
• 金额: $ 12.68万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6342349
• 关键词: amygdala; behavior test; chemoreceptors; computer data analysis; ethology; medial olfactory area; neural information processing; neural transmission; neuroanatomy; neurons; olfactory lobe; predation; prosencephalon; sensorimotor system; sex behavior; snakes; vomeronasal systems

DESCRIPTION (Applicant's abstract): The main olfactory and vomeronasal systems are major chemosensory systems that guide animal behavior in response to changing environmental cues. The dual olfactory system hypothesis postulates that these two systems comprise parallel pathways through the telencephalon and, by virtue of these connections, are involved in different aspects of behavioral response to chemical stimuli. Recent findings indicate that neurons in the main olfactory and vomeronasal systems terminate in different nuclei of the amygdaloid complex and converge on other telencephalic nuclei. These anatomical relationships and the roles of the central neural structures involved in response to prey-derived chemicals are the subjects of our research. We are using snakes to study the vomeronasal and olfactory systems and the interactions between these two systems because snakes have extraordinary well-developed vomeronasal systems that are of critical importance in naturally occurring behaviors such as courtship, prey discrimination and aggregation. Parallel work in other laboratories using mammals has demonstrated the applicability and generality of our findings to other vertebrates. We will continue to explore the anatomical connections of these systems and to study the roles of their central nervous system components in responding to prey chemicals by determining the effects of various lesions on discriminated response to prey chemicals. The sites of their lesions will be the terminations of mitral cell axons from the olfactory bulbs and their further projections in the central nervous system.

描述（申请人的摘要）： 主要的嗅觉和呕吐系统是主要的化学感觉 指导动物行为以响应不断变化的环境的系统 提示。双重嗅觉系统假设假设这两个 系统包括通过端脑的平行途径，以及 这些联系的优点与 对化学刺激的行为反应。最近的发现表明 主嗅觉和呕吐系统中的神经元终止 杏仁核复合物的不同核并收敛于其他 脑脑核。这些解剖学关系和 响应猎物衍生的涉及的中央神经结构 化学物质是我们研究的主题。我们正在使用蛇学习 沃梅隆和嗅觉系统以及这些系统之间的相互作用 两个系统，因为蛇具有非凡的发达的vomeronasal 在自然发生的行为中至关重要的系统 例如求爱，猎物歧视和聚集。平行工作 在其他实验室中，使用哺乳动物证明了适用性 我们发现对其他脊椎动物的一般性。我们将继续 探索这些系统的解剖联系，并研究 其中枢神经系统成分在反应猎物中的作用 化学物质通过确定各种病变对歧视的影响 对猎物化学物质的反应。他们病变的部位将是 从嗅球及其的二尖瓣轴突终止 中枢神经系统的进一步预测。