Heterogeneity in the Vomeronasal System

犁鼻系统的异质性

• 批准号: 6516145
• 负责人: MIMI N. HALPERN
• 金额: $ 27.54万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516145
• 关键词: G protein; Golgi apparatus; SDS polyacrylamide gel electrophoresis; amygdala; biological polymorphism; calcium ion; cell population study; chemoreceptors; electrophysiology; epithelium; estrus; gender difference; genetic polymorphism; immunocytochemistry; neuroanatomy; neurons; odors; olfactory lobe; opossums; pheromone; phosphorylation; protooncogene; stimulus /response; tissue /cell preparation; vomeronasal systems

DESCRIPTION: The vomeronasal system of mammals is chemoarchitecturally heterogeneous. Two populations of receptor cells, located at different depths of the vomeronasal sensory epithelium, project to different portions of the accessory olfactory bulb. We will continue to investigate this heterogeneity by investigating functional differences between the two portions of the vomeronasal system using a variety of techniques. We will determine whether the anterior or posterior accessory bulb is critical for response to pheromones involved in estrous cycling. We will determine which subdivision of the vomeronasal system is activated by odors from same-sex and opposite-sex conspecifics using anatomical, calcium imaging and electrophysiological techniques. We will determine the source(s) of pheromonal odors and conduct preliminary purification of these pheromones. We will investigate whether olfactory marker protein expression can be induced by pheromonal odors. At the completion of these studies we will be able to state whether the two parts of the vomeronasal system are differentially involved in behaviors shown to use vomeronasallymediated stimuli.

描述：哺乳动物的呕吐系统是化学结构 异质。两个位于不同深度的受体细胞种群 在伏美诺纳纳斯感觉上皮中，投影到不同部分的 附件嗅球。我们将继续通过 研究两部分之间的功能差异 使用多种技术的沃马纳纳纳斯系统。我们将确定是否 前或后附件灯泡对于对信息素的反应至关重要 参与发情骑自行车。我们将确定哪个细分 来自同性和相反性的气味激活了沃马纳纳纳斯系统 使用解剖学，钙成像和电生理学 技术。我们将确定信息源性气味的来源 这些信息素的初步纯化。我们将调查是否 嗅觉标记蛋白表达可以通过信息符号的气味诱导。在 完成这些研究的完成，我们将能够说明是否 Vomeronasal系统在显示的行为中有不同的参与 呕吐刺激的刺激。