CHRONIC DISEASE RISKS ASSOCIATED WITH MERCURY VAPOR EXPOSURE

与汞蒸气接触相关的慢性疾病风险

• 批准号: 6106698
• 负责人: Andrew S. Rowland
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106698
• 关键词: chronic renal failure; clinical research; dental amalgam; disease /disorder proneness /risk; environmental toxicology; human data; human subject; hypertension; hypothalamic pituitary axis; laboratory rat; mercury poisoning; nitrous oxide; occupational health /safety; ovary disorder

Summary of Work: We are collaborating with researchers from the National Institute of Diabetes and Digestive and Kidney Diseases and the American Dental Association of the risk of end stage renal disease among dentists exposed to mercury and nitrous oxide. We are comparing 138,000 U.S. dentists who graduated before 1977 with the U.S. renal disease registry to see whether general dentists who are highly exposed to mercury have higher rates of renal failure than orthodontists and other subspecialties who have lower exposures. We will also look whether oral surgeons and pedodontists who have elevated nitrous oxide exposures have increased rates. Initial analyses suggest that there is an excess risk of ESRD among general dentists compared to dental specialists which is consistent with the study hypothesis. Dr. Bjorkman (a research fellow at the Karolinska Institute in Sweden, Dr. Sandler, and I are analyzing data from NHANES I to look at the relationship between the number of dental amalgams in a person's mouth and their diastolic blood pressure. The hypothesis is that like lead, mercury might disrupt renal function and increase the risk of hypertension. Initial findings suggest an increased risk among young men and middle age women but are not elevated in any of the 4 other age-sex groups. This is therefore suggestive of a possible effect but so inconsistent that it may not be casually related.

工作总结：我们正在与 来自国家糖尿病和消化研究所的研究人员 和肾脏疾病和美国牙科协会 接触汞的牙医患终末期肾病的风险 和一氧化二氮。我们正在比较 138,000 名美国牙医，他们 1977 年之前在美国肾脏疾病登记处毕业 高度接触汞的普通牙医是否有 肾衰竭发生率高于正牙医生和其他医生 暴露程度较低的亚专业。我们也会看看 口腔外科医生和儿牙科医生是否患有高亚硝酸盐 氧化物暴露率有所增加。初步分析表明 与普通牙医相比，ESRD 的风险较高 与研究假设一致的牙科专家。 Bjorkman博士（卡罗林斯卡学院研究员） 瑞典、桑德勒博士和我正在分析 NHANES I 的数据 看看牙科汞合金的数量之间的关系 人的口腔及其舒张压。假设是 与铅一样，汞可能会破坏肾功能并增加 高血压的风险。初步发现表明风险增加 但在年轻男性和中年女性中并未升高 任何其他 4 个年龄性别组。因此，这暗示了一个 可能有效果，但不一致，可能不是随意的 有关的。