The Natural Histroy of ADHD in a Population-Based Sample

基于人群的样本中 ADHD 的自然史

• 批准号: 7125965
• 负责人: Andrew S. Rowland
• 金额: $ 51.32万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-26 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125965
• 关键词: African American; adolescence (12-20); attention; attention deficit disorder; behavioral /social science research tag; child psychology; clinical research; gender difference; human subject; interview; mental health epidemiology; pathologic process; patient oriented research; racial /ethnic difference

DESCRIPTION (provided by applicant): Knowledge about the natural history of attention-deficit/hyperactivity disorder (ADHD) is limited because most follow-up studies have been conducted on clinic samples of hyperactive, white, boys. It is not clear how relevant these data are for children identified with ADHD in community settings. In addition, little information is available about the developmental course of ADHD in girls, adolescents, African-Americans, or children with the Inattentive type of ADHD. The proposed longitudinal follow-up study will describe the natural history of ADHD in a population-based sample of children (448 with ADHD, 444 controls, and 134 borderline ADHD cases.) Between 1998 and 2000, all the elementary school children in a diverse semi-rural North Carolina County were screened for ADHD as part of an epidemiologic study. Teachers completed rating scales and parents were interviewed about their child's symptoms, medical history and life events. The proposed study will re-evaluate these same children eight to ten years later as adolescents using in-person youth interviews, parent telephone interviews, teacher rating scales, and abstracted school records. This information will be used to estimate the persistence and describe the developmental course of ADHD and its types, to estimate the risk of adverse health behaviors (smoking, drug and alcohol abuse, and accidents), to estimate comorbidity and impairment, and to evaluate whether stimulant medication treatment, as it is being administered in this community setting, is associated with improved outcomes. This study will add to current knowledge about the developmental course and public health impact of ADHD in a population based sample that includes previously under-studied populations - i.e., girls, African Americans, and children with the Inattentive Type of ADHD.

描述（由申请人提供）：关于注意力缺陷/多动障碍（ADHD）自然史的知识有限，因为大多数后续研究都是针对多动的白人男孩的临床样本进行的。目前尚不清楚这些数据对于社区环境中患有多动症的儿童有何相关性。此外，关于患有注意力缺陷多动症的女孩、青少年、非裔美国人或儿童的注意力缺陷多动症发展过程的信息很少。 拟议的纵向随访研究将描述基于人群的儿童样本（448 名 ADHD 儿童、444 名对照儿童和 134 名边缘 ADHD 病例）中 ADHD 的自然史。1998 年至 2000 年间，作为流行病学研究的一部分，对北卡罗来纳州半农村地区的多动症进行了筛查。老师们完成了评分量表，家长们接受了关于孩子症状、病史和生活事件的采访。 拟议的研究将在八到十年后，通过面对面的青少年访谈、家长电话访谈、教师评分量表和抽象的学校记录，重新评估这些青少年的孩子。这些信息将用于估计 ADHD 及其类型的持续性和发展过程，估计不良健康行为（吸烟、吸毒和酗酒以及事故）的风险，估计合并症和损伤，并评估是否在该社区环境中进行的刺激性药物治疗与改善结果相关。这项研究将增加目前关于 ADHD 的发展过程和公共健康影响的知识，该样本以人群为基础，其中包括以前研究不足的人群，即女孩、非裔美国人和患有注意力不集中型 ADHD 的儿童。