RISK FACTORS FOR ATTENTION DEFICIT/HYPERACTIVITY DISORDER

注意力缺陷/多动症的危险因素

• 批准号: 6289998
• 负责人: Andrew S. Rowland
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289998
• 关键词: alcoholic beverage consumption; attention deficit disorder; clinical research; disease /disorder etiology; disease /disorder proneness /risk; dosage; embryo /fetus toxicology; environmental health; human subject; lead poisoning; mental health epidemiology; middle childhood (6-11); premature labor; tobacco abuse

The purpose of this project is to evaluate environmental, reproductive, and familial risk factors for ADHD within a population-based cohort. We are in the process of screening all 8,000 elementary school students in the Johnston County School system for ADHD, first through teacher completed forms and later through parent interviews. The primary aims of the project are to describe the prevalence of ADHD and how it varies by age, race, gender, and SES, to test the hypothesis that preterm and post-term births are at higher risk for ADHD and to evaluate the role of maternal smoking, maternal occupation, maternal alcohol consumption and pregnancy complications as risk factors for ADHD.We have developed a practical method to apply clinical case criteria for ADHD to an epidemiologic setting. This allows us to provide important information that has not previously been available on prevalence, risk factors, and treatment patterns of ADHD.In the first year of data collection, we obtained an 83% response rate in screening the first 8 schools. Our initial data suggest the prevalence of diagnosed ADHD is about 10% and that about 7% of all children in the elementary schools are taking medication to treat ADHD. After screening the population, data from a pretest conducted in 4 schools suggests that the true prevalence might be about 15%, three times the official estimate from DSM-IV. In addition, we found that almost 40% of the cases had not been previously diagnosed and almost a third of the children being treated with medication were still showing enough symptoms and impairment to look like cases. - Attention Deficit Disorder, preterm birth, ADHD, lead, children, pesticides, epidemiology, behavior, - Human Subjects: Interview, Questionaires, or Surveys Only

该项目的目的是在基于人群的队列中评估 ADHD 的环境、生殖和家庭风险因素。我们正在对约翰斯顿县学校系统的所有 8,000 名小学生进行多动症筛查，首先通过老师填写的表格，然后通过家长访谈。该项目的主要目的是描述 ADHD 的患病率以及它如何随年龄、种族、性别和社会经济地位的变化而变化，检验早产和过期产 ADHD 风险较高的假设，并评估 ADHD 的作用。母亲吸烟、母亲职业、母亲饮酒和妊娠并发症都是 ADHD 的危险因素。我们开发了一种实用方法，将 ADHD 的临床病例标准应用于流行病学环境。这使我们能够提供以前无法获得的有关多动症患病率、危险因素和治疗模式的重要信息。在数据收集的第一年，我们在筛选前 8 所学校时获得了 83% 的答复率。我们的初步数据表明，诊断出的 ADHD 患病率约为 10%，并且大约 7% 的小学儿童正在服用治疗 ADHD 的药物。在对人群进行筛查后，在 4 所学校进行的预测试数据表明，真实患病率可能约为 15%，是 DSM-IV 官方估计值的三倍。此外，我们发现近 40% 的病例之前并未被诊断出来，并且近三分之一正在接受药物治疗的儿童仍然表现出足够的症状和损伤，看起来像病例。 - 注意力缺陷障碍、早产、多动症、铅、儿童、农药、流行病学、行为 - 人类受试者：仅限访谈、问卷或调查