Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery

使用具有动态重排和自我恢复能力的单体增强牙科粘合剂

• 批准号: 10174916
• 负责人: Caroline Rose Szczepanski
• 金额: $ 15.68万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10174916
• 关键词: 3-Dimensional; Address; Adhesives; Amalgam; Appearance; Award; Bacteria; Behavior; Biocompatible Materials; Biological; Bone Tissue; Catechols; Categories; Chicago; Clinical; Complement; Complex; Dental Materials; Dental Schools; Dentin; Development; Development Plans; Ensure; Environment; Esthetics; Exposure to; Failure; Fatigue; Formulation; Funding; Goals; Growth; Healthcare; Heterogeneity; Hybrids; Hydrogen Bonding; Illinois; Infiltration; Investigation; Laboratory Research; Longevity; Mechanical Stress; Mechanics; Medicine; Mentors; Mentorship; Methacrylates; Michigan; Modeling; Morphology; National Institute of Dental and Craniofacial Research; Oral; Patient Care; Patients; Performance; Phase; Plant Resins; Polymers; Positioning Attribute; Postdoctoral Fellow; Protocols documentation; Pyrimidinones; Recovery; Relaxation; Research; Research Personnel; Research Project Grants; Route; Science; Series; Specimen; Stress; Structural Models; Structure; System; Testing; Training; United States; United States National Institutes of Health; Universities; Water; Work; analog; biomaterial compatibility; career; career development; chemical group; composite restoration; cost; dental adhesive; design; driving force; improved; innovation; mechanical properties; monomer; novel; oral care; photopolymerization; polymerization; programs; research and development; response; responsible research conduct; restoration; restorative dentistry; restorative material; skills; success; uptake

Project Summary The long-term goal of the award applicant is to establish a competitive, independently funded research program that develops robust materials to address healthcare challenges. This goal will be realized through the execution of an organized, thorough, and integrated career development plan, effective mentorship, and an engaging and innovative research project. The proposed research project will investigate phase separation in self-etch adhesive resins and explore the use of monomers capable of adaptable, dynamic hydrogen bonding to improve overall adhesive performance. The three aims of this project will address the hypothesis that phase separation during adhesive polymerization forms weakened domains of the hybrid layer, which must be reinforced to ensure robust adhesive performance. To this end, the first goal of the research project is to study phase separation in model self-etch adhesives and to ascertain the resulting composition and morphology of heterogeneous domains that result during polymerization. The second goal of the research project is to develop a series of methacrylate monomers decorated with two different hydrogen bonding groups (catechol, and ureido-4[1H]-pyrimidinone – UPy) and ascertain their performance in adhesive resins and efficacy at rearranging in response to applied stresses. The career development proposed for Dr. Caroline Szczepanski includes training in relevant experimental protocols to assess the performance, biocompatibility, and stability of polymeric materials intended for oral care. Additionally, broad training in skills necessary for the management of an independent career and funded research laboratory (e.g. grantsmanship, lab management) will be addressed. These goals are complemented by the choice of mentors and the institutional environment which will all assist in providing the skills and guidance needed by the applicant to develop a successful research program and succeed as an independent investigator. The mentor team will consist of Prof. Ana Bedran-Russo (University of Illinois Chicago – UIC), Prof. Christina Chan (Michigan State University - MSU) and Prof. Marco Bottino (University of Michigan). Profs. Bedran-Russo and Bottino will provide critical guidance and training in the analysis of material performance in simulated oral environments (e.g. micro-tensile bond testing), as well as the use of dentin specimens to assess adhesive efficacy. Since both Profs. Bedran-Russo and Bottino are affiliated with schools of dental medicine, they will also provide Dr. Szczepanski with opportunities to attend research seminars, meet fellow researchers, and network within this new field of research. Prof. Chan will provide mentorship particularly focused on grantsmanship as well as navigating the path towards reappointment and tenure at MSU. In addition to these mentors, Dr. Szczepanski’s career development plan includes seminars in the grantsmanship, responsible conduct of research, and mentorship will be pursued throughout the award period. Together, the proposed research and career development plan will build upon the applicant’s expertise in polymer science to situate themselves as a significant contributor to NIDCR and NIH relevant research.

项目概要 奖项申请者的长期目标是建立一个有竞争力的、独立资助的研究项目 开发强大的材料来应对医疗保健挑战这一目标将通过执行来实现。 一个有组织的、彻底的、综合的职业发展计划、有效的指导以及有吸引力的和 拟议的研究项目将研究自蚀刻中的相分离。 粘合剂树脂并探索使用具有适应性、动态氢键作用的单体来改善 该项目的三个目标将解决相分离的假设。 在粘合剂聚合过程中形成混合层的弱化区域，必须对其进行加固以确保 为此，该研究项目的首要目标是研究相分离。 模拟自蚀刻粘合剂并确定异质域的组成和形态 该研究项目的第二个目标是开发一系列甲基丙烯酸酯。 带有两个不同氢键基团（儿茶酚和脲基-4[1H]-嘧啶酮）修饰的单体 – UPy）并确定它们在粘合树脂中的性能以及响应应用而重新排列的功效 为 Caroline Szczepanski 博士提出的职业发展建议包括相关培训。 评估预期聚合物材料的性能、生物相容性和稳定性的实验方案 此外，还接受管理独立职业所需的广泛技能培训。 资助的研究实验室（例如资助、实验室管理）将得到解决。 导师的选择和制度环境都将有助于提供 申请人开发成功的研究计划并取得成功所需的技能和指导 导师团队将由 Ana Bedran-Russo 教授（伊利诺伊大学芝加哥分校）组成。 – UIC）、Christina Chan 教授（密歇根州立大学 - MSU）和 Marco Bottino 教授（密歇根大学）。 Bedran-Russo 和 Bottino 教授将提供材料分析方面的重要指导和培训 模拟口腔环境中的性能（例如微拉伸粘合测试）以及牙本质的使用 由于 Bedran-Russo 教授和 Bottino 教授都隶属于学校，因此需要使用样本来评估粘合效果。 牙科医学方面，他们还将为 Szczepanski 博士提供参加研究研讨会、会面的机会 陈教授将特别为这一新研究领域的研究人员和网络提供指导。 此外，我们还专注于资助以及为密歇根州立大学的重新任命和终身教职做好准备。 对于这些导师来说，Szczepanski 博士的职业发展计划包括资助研讨会、 在整个奖励期间将共同追求负责任的研究和指导。 拟议的研究和职业发展计划将建立在申请人在聚合物科学方面的专业知识的基础上 将自己定位为 NIDCR 和 NIH 相关研究的重要贡献者。