CORE--LABORATORY ANIMALS

核心——实验动物

• 批准号: 6311457
• 负责人: JAMES O STEVENS
• 金额: $ 14.76万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2001-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6311457
• 关键词: animal colony; biomedical facility; germ free condition; histopathology; information systems; laboratory rat; serology /serodiagnosis

The Aging and Alzheimer's Research Center Laboratory Animal Core operates as a shared resource which facilitates, enriches and coordinates animal model studies for four of the five component projects in the Center proposal. This Core has, over previous grant and project periods, developed and maintained barrier-sustained, disease-free colonies of conventional, aged, ultra-aged and lifetime (more 39 months) caloric restricted, neurologically modeled rats in order to reduce data compromising animal variables for new and ongoing studies. We have eliminated infectious agents from all experimental colonies, constructed and renovated new barriered housing areas, established improved environmental conditions for housing behavioral modeled research animals with behavioral testing laboratories contiguous to animal housing rooms. One specific aim of this core component is to continue to provide specialized maintenance of barrier sustained transplant, conventional, caloric-restricted, 6-OHDA modeled and control aged rats. The core will continue to facilitate all aspects of animal model studies as previously developed and implemented. A second specific aim is to provide other core services to Aging Center investigators including comprehensive gross and histopathological evaluations of experimental animals, serological surveillance to document a continuing virus (especially parvovirus) and mycoplasma disease-free status and continuous consultation on laboratory animal genetics, modeling and spontaneous disease evaluations in aged rats. A third specific aim is to maintain and provide Center investigators with nutritionally (caloric) restricted, aged (more 30 months) Fisher 344 rats. In the fourth specific aim, the Core Director will develop a nw, automated data base which will include, monitor and track all experimental animals used in all projects. All project animals will be uniquely identified with implanted with electronic, transponder microchips. This database will be networked to and be accessible by all Center investigators. The Core will coordinate the use of all animals within and between projects in order to maximize the efficiency of animal use and eliminate any potential unnecessary and redundant animal use.

衰老与阿尔茨海默氏症研究中心实验动物核心运营 作为促进、丰富和协调动物的共享资源 该中心五个组成项目中的四个的模型研究 提议。 该核心在之前的拨款和项目期间， 开发并维持屏障持续、无病的菌落 常规、老化、超老化和终生（超过 39 个月）热量 限制性神经模型大鼠以减少数据 为新的和正在进行的研究牺牲动物变量。 我们有 从所有实验菌落中消除感染因子，构建 并改造了新的隔离住房区，建立了改进的 饲养行为模型研究动物的环境条件 行为测试实验室毗邻动物饲养室。 该核心组件的一个具体目标是继续提供 屏障持续移植的专业维护，常规， 热量限制、6-OHDA 建模和对照老年大鼠。 核心将 继续像以前一样促进动物模型研究的各个方面 制定并实施。 第二个具体目标是提供其他核心 为老龄化中心调查人员提供的服务，包括全面的总体和 实验动物的组织病理学评估、血清学评估 监视以记录持续存在的病毒（尤其是细小病毒）和 支原体无病状况及实验室持续会诊 老年大鼠的动物遗传学、建模和自发性疾病评估。 第三个具体目标是维持并为中心调查人员提供 营养（热量）受限、老年（30 个月以上）Fisher 344 只大鼠。 在第四个具体目标中，核心总监将开发一个新的、自动化的 数据库将包括、监测和跟踪所有实验动物 在所有项目中使用。 所有项目动物都将被唯一标识 植入电子应答器微芯片。 该数据库将是 与所有中心调查员联网并可供其访问。 核心将 协调项目内和项目之间所有动物的使用，以便 最大限度地提高动物利用效率并消除任何潜在的 不必要和多余的动物使用。