CORE--IMMUNODEFICIENT RODENT /LABORATORY ANIMAL FACILITY

核心--免疫缺陷啮齿动物/实验动物设施

基本信息

批准号：
6504956
负责人：
JAMES O STEVENS
金额：
$ 6.18万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-05-01 至 2003-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6504956
关键词：
SCID mouse animal colony athymic mouse biomedical facility disease /disorder model histopathology immunodeficiency laboratory mouse laboratory rat lung neoplasms neoplasm /cancer transplantation xenotransplantation

项目摘要

The overall objective of this SPORE Immunodeficient Rodent laboratory Animal Core is to facilitate preclinical research in human lung cancer through the use of orthotopic cancer cell and tissue transplants (xenografts) in animal models. This shared resource will provide purchase, production breeding of and maintenance for specific pathogen-free, barrier- sustained, conventional, and severe-combined-immunodeficient (SCID) mice and athymic nude rats and mice for use by SPORE investigators in research projects in this program. This CORE will also provide gross and histopathology services, transgenic animal services, cancer will inoculation transfers, and harvests and animal model preparations for all program investigators using animal models. This CORE will maintain production colonies of pneumocystis carinii-free athymic nude rats and SCID mice in order to provide the necessary pulmonary disease-free animals required for these lung cancer studies. Animal studies supported by this CORE are focused on the primary SPORE Program objective which is to decrease incidence and mortality from lung cancer by discovery of cellular and molecular events involved in the progression of lung cancer and the translation of these discoveries into clinical applications.

SPORE 免疫缺陷啮齿动物实验室的总体目标 Animal Core 将促进人类肺癌的临床前研究通过使用原位癌细胞和组织移植（异种移植）在动物模型中。此共享资源将提供购买、特定无病原体、无障碍的生产育种和维护持续性、常规性和严重联合免疫缺陷 (SCID) 小鼠以及 SPORE 研究人员在研究中使用的无胸腺裸大鼠和小鼠该计划中的项目。该核心还将提供总和组织病理学服务、转基因动物服务、癌症将所有人的接种转移、收获和动物模型准备项目研究人员使用动物模型。这个核心将维持无卡氏肺孢子虫无胸腺裸鼠生产菌落及SCID 小鼠以提供必要的肺部无疾病动物这些肺癌研究所需的。动物研究受此支持 CORE 专注于 SPORE 计划的主要目标，即通过发现细胞因子降低肺癌的发病率和死亡率以及参与肺癌进展的分子事件将这些发现转化为临床应用。