CORE--LABORATORY ANIMALS

核心——实验动物

• 批准号: 6664426
• 负责人: JAMES O STEVENS
• 金额: $ 25.04万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-06 至 2003-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6664426
• 关键词: SCID mouse; antitumor antibody; athymic mouse; biomedical facility; disease /disorder model; germ free condition; laboratory rat; model design /development; monoclonal antibody; neoplasm /cancer

Description: (Applicant's Description) The Laboratory Animal Shared Core Resource continues to provide animal services to Cancer Center members at discounted rates. In addition to services previously provided we have added a treatment and tumor assessment service. The transgenic animal production services which were previously included in this core are now provided and described in the Transgenic/Knockout core. The Laboratory Animal core began operation in 1987, now consists of the original laboratory animal components plus the new animal model tumor testing and intervention service. The core presently serves the research animal needs of 88 Cancer Center investigators including 74 who utilize full core services in the Center for Laboratory Animal Care on the UCHSC campus. The overall objective of the core is to facilitate cancer research and provide Cancer Center investigators with high quality, centralized and specialized services for animal experimentation at reduced and cost effective prices. This shared resource provides routine and specialized maintenance of conventional and barrier- sustained, specific-pathogen-free (SPF) rodents, conventional laboratory animals and transgenic/knockout rodents as well as severe combined immunodeficient (SCID) and athymic, nude mice and rats for allo- and xenografts of tumors and tumor testing, growth and intervention studies. New therapies may be delivered by intravenous, intraperitoneal, transtracheal, intratumoral, intragenic or other routes. Samples for pharmacokinetic analysis are collected for evaluation in the Pharmacology core. The Laboratory Animal core also provides monoclonal and polyclonal antibody production services, gross and histopathology, medical photography and photo microscopy , tumor harvests and transfers, animal model development, preparations and manipulations, training in animal research techniques and laboratory animal veterinary services. The primary goal is to provide state of the art, high quality animal maintenance and research services to Cancer Center investigators that are affordable and accessible.

描述：（申请人的描述）实验室动物共享核心 资源继续向癌症中心成员提供动物服务 折扣率。除了以前的服务，我们还添加了 治疗和肿瘤评估服务。转基因动物产量 现在提供了以前在此核心中包含在此核心中的服务，并且 在转基因/敲除核心中描述。实验室动物核心开始 1987年的操作现在由原始的实验室动物组件组成 加上新的动物模型肿瘤测试和干预服务。核心 目前满足88个癌症中心研究人员的研究动物需求 包括74名在实验室中心使用全方位核心服务的人 UCHSC校园的动物护理。核心的总体目标是 促进癌症研究，并为癌症中心研究人员提供高 在动物实验的质量，集中和专业服务 降低和成本效益的价格。 此共享资源提供了常规和专业维护 常规和屏障 - 持续的，特异性的无病因（SPF）啮齿动物， 常规的实验室动物和转基因/敲除啮齿动物以及 严重的联合免疫缺陷型（SCID）和无心nude小鼠和大鼠 肿瘤和肿瘤测试，生长和干预的异种和异种移植 研究。新疗法可以通过静脉内，腹膜内提供 经口径，肿瘤内，内部或其他路线。样品 收集药代动力学分析以评估药理学 核。实验室动物核心还提供单克隆和多克隆 抗体生产服务，总体和组织病理学，医学摄影 以及照片显微镜，肿瘤收获和转移，动物模型发展， 准备和操纵，动物研究技术的培训和 实验室动物兽医服务。主要目标是提供状态 艺术，高质量的动物维护和癌症研究服务 中心调查人员负担得起且可访问。