CORE--CLINICAL CORE

核心--临床核心

• 批准号: 6237393
• 负责人: GERALD J KUTCHER
• 金额: $ 39.09万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6237393
• 关键词: biomedical equipment development; biomedical facility; clinical research; computed axial tomography; computer assisted patient care; computer program /software; data collection; human subject; human therapy evaluation; neoplasm /cancer radiation therapy; patient care planning; radiation therapy dosage; relative biological effectiveness

The clinical core is comprised of 3 major tasks: treatment planning; (2) development of simulator and portal imaging network (SPIN); (3) development of interventional therapy with CT (CT-guided treatment. (1) Treatment Planning: The treatment planning core is responsible for planning approximately 65 patients per year for the prostate and lung dose escalation studies. Prostate treatment will generally involve intensity modulation delivered with dynamic multileaf-collimator (DMLC). Lung treatments will be done in deep inspiration breath-hold (DIBH). The core will also be responsible for the safe and accurate delivery of these treatments and will participate in the analysis. In additoin, the core will do acceptance testing and on-going QS on all software developed in Projects II-IV that is used to plan and/or treat patients. Finally, all documentation of patient records will be maintained by the core. (2) SPIN: This client-based server network will be enhanced tomeet the needs of Research Projects I- IV. It will provide integration of the 3D planning system with SPIN which will be used by Research Project I patients. It will provide on-line analysis for measuring patient setup error, verification of DMLC treatments, portal imaging verification of DIBH treatments, and interventional changes required with CT- guided treatment. Finally, it will expand it physical resources to meet increased QA needs. (3) CT-guided treatment: Tools will be developed for Research Project IV in which it is proposed to study treatments in which a patient is scanned prior to treatment, the change in patient~s setup required to register the prostate and treatment field is determined from the CT scans, and the patient is transported to and positioned on the treatment unit in the corrected position. The core will: (a) develop a method to immobilize the patient in a rigid device with licalization markers, (b) implement and test software tools (manual and possibly automatic) to determine the change in positoin required to register the tumor and treatment field, (c) develop a method to transport the patient smoothly and CT unit to the treatment machine and accurately position the patient.

临床核心由3个主要任务组成：治疗 规划; （2）模拟器和门户成像的开发 网络（旋转）; （3）开发介入疗法 CT（CT引导治疗。（1）治疗计划：治疗 计划核心负责计划大约65 前列腺和肺剂量升级研究的患者。 前列腺治疗通常涉及强度调节 用动态多eaf-Collimimator（DMLC）交付。 肺 治疗将以深刻的灵感呼吸（DIBH）进行。 核心还将负责安全准确 提供这些治疗方法，并将参与分析。在 添加剂，核心将进行接受测试和正在进行的QS 在项目II-IV中开发的所有软件，用于计划和/或 治疗患者。 最后，所有患者记录的文档将 由核心维护。 （2）旋转：基于客户端的服务器 网络将增强TOMEET的研究项目需求I- iv。 它将提供3D计划系统的集成 研究项目患者将使用的旋转。 会 提供在线分析以测量患者设置错误， 验证DMLC处理，门户成像验证 DIBH处理以及CT-需要进行的介入更改 指导治疗。 最后，它将扩大其物理资源 满足增加的质量检查需求。 （3）CT引导的处理：工具将是 为研究项目IV开发的，该项目提议研究 治疗前扫描患者的治疗 注册前列腺所需的患者设置的更改和 从CT扫描确定治疗场，患者是 运输到校正后的治疗单元并放在 位置。核心将：（a）开发一种固定的方法 患者在带有螺母标记的刚性设备中，（b）实施 以及测试软件工具（手动和可能自动） 确定注册肿瘤所需的正石变化，并 治疗领域，（c）开发一种运输患者的方法 平稳和CT单位到治疗机，并准确 定位病人。