CORE--CLINICAL CORE

核心--临床核心

• 批准号: 5209274
• 负责人: GERALD J KUTCHER
• 金额: --
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5209274
• 关键词: biomedical facility; clinical biomedical equipment; computed axial tomography; data collection; human subject; human therapy evaluation; neoplasm /cancer radiation therapy; patient care planning; relative biological effectiveness

The primary functions of the Clinical Core are in planning and implementing 3D conformal radiation therapy for patients chosen for the clinical studies of this Program Project. The Clinical Core is involved in the development of treatment protocols, is primarily responsible for obtaining patient specific information and for designing treatment plans, and it plays a key role in assuring the safe and accurate implementation of the multi-field treatments. In carrying out these tasks, the Clinical Core draws on and coordinates the resources of the other Cores. Specifically, the Clinical Core uses the programs developed by the Computer Core and the dosimetric data collected by the Dosimetry Core. In addition, with the progress of the Program Project, when new treatment planning tools become available from Research Project II, as well as new dosimetric and calculational techniques from Research Project III, the Clinical Core will test these programs and implement them. The Clinical Core will also provide support to the Research Projects. It provides support for conducting Research Project I (Clinical Investigations). For research on plan evaluation (Project II) and patient set-up uncertainty (Project III), the Clinical Core will coordinate the collection of clinical data, and participate in their evaluation. It will also support the computer-aid optimization project (Research Project II) by providing feedback and clinical evaluation. In as much as that we shall use equipment such as the multi-leaf collimators and the on-line imagers, which are new technologies, we plan to evaluate them and develop quality assurance protocols, and procedures for their use. The Clinical Core will also participate in the development of the methods and procedures to verify the accuracy of the dose delivery using on-line imager and in-vivo dosimetry.

临床核心的主要功能是计划和实施 为临床研究选择的患者的3D共形辐射疗法 这个程序项目。 临床核心参与了开发 治疗方案的主要负责 具体信息和设计治疗计划，它发挥了关键 确保安全实施多场的角色 治疗。 在执行这些任务时，临床核心借鉴并 协调其他核心的资源。 具体而言，临床 核心使用计算机核心开发的程序和剂量计 剂量核心收集的数据。 另外，随着进步 计划项目，新的治疗计划工具可用 从研究项目以及新的剂量学和计算 研究项目III的技术，临床核心将测试这些 程序并实施它们。 临床核心还将为研究项目提供支持。 它 为进行研究项目提供支持（临床 调查）。 用于计划评估（项目II）和患者的研究 设置不确定性（项目III），临床核心将协调 收集临床数据，并参与他们的评估。 会 还支持计算机AID优化项目（研究项目II） 提供反馈和临床评估。 尽可能多地 使用诸如多叶准准直仪和在线成像器之类的设备， 这是新技术，我们计划评估它们并发展质量 保证协议和使用程序。 临床核心将 还参与了验证方法和程序的开发 使用在线成像仪和体内的剂量递送的准确性 剂量测定。