NEUROBIOLOGY OF ATTENTION DEFICIT DISORDER

注意力缺陷障碍的神经生物学

• 批准号: 4696501
• 负责人: J L RAPOPORT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696501
• 关键词: adult human (21+); aggression; attention deficit disorder; behavior test; blood chemistry; brain metabolism; catecholamines; cerebrospinal fluid; child (0-11); glucose metabolism; human subject; human therapy evaluation; male; mental disorder chemotherapy; neurotransmitter metabolism; phenylalanine; social behavior disorders; urinalysis

Attention Deficit Disorder with Hyperactivity (ADDH) is a life-long disability affecting approximately 4% of school age children. To understand the pathophysiology of this disorder and to develop new treatments, a therapeutic trial of the amino acid, d-phenylalanine, was completed over the past nine months. Eleven ADDH boys participated in a placebo controlled double blind evaluation of phenylalanine (10/mg/kg/day) and placebo. Behavioral data and biochemicl measures in urine and plasma are being analyzed at present and results are forthcoming. In an attempt to localize abnormal patterns of cerebral glucose metabolism and cerebral flow in adults with Attention Deficit Disorder (ADD) Residual Type, fathers of diagnosed hyperactive children are being studied using the 2-deoxyfluoroglucose method of Positron Emission Tomography (PET). To date, four patients have been scanned. Because of reports that the spinal fluid (CSF) 5HIAA, a serotonin metabolite, may be low in severely impulsive or aggressive adults, a study has been initiated to compare spinal fluid catecholamine and indoleamine metabolites in severely aggressive, conduct disordered children with and without ADD to children with other neurological problems. Peripheral measures of catecholamines will also be obtained.

注意力缺陷多动障碍（ADDH）是一种终生的疾病 残疾影响了大约 4% 的学龄儿童。 到 了解这种疾病的病理生理学并开发新的 治疗，一项氨基酸 d-苯丙氨酸的治疗试验 过去九个月内完成。 十一名 ADDH 男孩参加了 苯丙氨酸安慰剂对照双盲评估（10/mg/kg/天） 和安慰剂。 尿液和血浆中的行为数据和生化测量 目前正在分析中，结果即将出炉。 试图定位脑葡萄糖代谢的异常模式 患有注意力缺陷障碍（ADD）残留的成人的脑流量和脑流量 类型，正在使用被诊断为多动症儿童的父亲进行研究 正电子发射断层扫描 (PET) 的 2-脱氧氟葡萄糖方法。 到 截至目前，已有四名患者接受了扫描。 因为有报道称脊髓液 (CSF) 5HIAA（一种血清素） 一项研究表明，在严重冲动或攻击性的成年人中，代谢物可能较低 已开始比较脊髓液儿茶酚胺和吲哚胺 严重攻击性、行为障碍儿童的代谢物 对患有其他神经系统问题的儿童没有ADD。 周边 还将获得儿茶酚胺的测量值。