NEUROBIOLOGY OF DISRUPTIVE BEHAVIOR DISORDERS

破坏性行为障碍的神经生物学

• 批准号: 6162862
• 负责人: J L RAPOPORT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6162862
• 关键词: Tourette's syndrome; adolescence (12-20); attention deficit disorder; behavioral /social science research tag; child (0-11); child behavior; clinical research; clinical trials; combination chemotherapy; dextroamphetamine; dosage; drug adverse effect; human subject; human therapy evaluation; interview; longitudinal human study; male; mental disorder chemotherapy; methylphenidate; neurobiology

A total of 20 boys completed this randomized 9-week, placebo-controlled, double-blind comparison of methylphenidate (MPH; Ritalin) and dextroamphetamine (DEX, Dexedrine) on tic severity in boys who have both attention-deficit/hyperactivity disorder (ADHD) as well as the tic disorder known as Tourette's syndrome. Relatively high doses of MPH and DEX produced significant increases in tic severity, but these were not generally sustained on Ritalin. Overall, 14 of 20 subjects continued stimulant treatment for 1 to 3 years, generally in combination with other medicines. Stimulant-associated adverse effects, including tic exacerbations, were reversible in all cases. The majority experienced improvement in ADHD symptoms with acceptable effects on tics. MPH was better tolerated than DEX.

共有 20 名男孩完成了这项为期 9 周、安慰剂对照的随机试验， 哌醋甲酯（MPH；利他林）和 右旋苯丙胺（DEX，Dexedrine）对患有这两种疾病的男孩抽动严重程度的影响 注意力缺陷/多动障碍 (ADHD) 以及抽动症 称为抽动秽语综合症的疾病。 相对较高剂量的 MPH 和 DEX 显着增加了抽动的严重程度，但这些并没有 一般靠利他林维持。 总体而言，20 门科目中有 14 门继续 兴奋剂治疗1至3年，一般与其他药物联合使用 药物。 兴奋剂相关的不良反应，包括抽动 恶化，在所有情况下都是可逆的。 大多数经历过 改善多动症症状，对抽动有可接受的效果。英里每小时是 比 DEX 具有更好的耐受性。