TREATMENT OF OBSESSIONAL CHILDREN AND ADOLESCENTS WITH CLOMIPRAMINE

用氯米帕明治疗强迫症儿童和青少年

• 批准号: 3921853
• 负责人: J L RAPOPORT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3921853
• 关键词: adolescence (12-20); antidepressants; basal ganglia; child mental disorders; clinical anxiety; clinical depression; hippocampus; human subject; human therapy evaluation; imipramine; longitudinal human study; mental disorder chemotherapy; mental health epidemiology; neuropsychological tests; neuropsychology; obsessive compulsive disorder; positron emission tomography

Obsessive Compulsive Disorder (ODD) is now recognized as a common mental disorder, occurring in perhaps four million people in this country alone. In adolescents, the prevalence may be one percent. Positron Emission Tomography with 18 adults with childhood onset OCD shows most significant increase in anterior cingulate and right prefrontal areas. This increase correlates with anxiety state during scan, severity of OCD, and clinical response to clomipramine. Fifty-one children and adolescents are enrolled in an ongoing double-blind comparison of clomipramine (CMI) and desmethylimipramine (DMI). DMI is virtually without benefit, while 70% of OC subjects receive at least some help from CMI. Trichotillomania (hair pulling) also appears to respond to CMI. Two single-blind and seven double-blind comparisons with DMI have been completed and results are more dramatic than for OCD. Adolescents with Sydenham's chorea have significantly higher incidence of OCD than controls with rheumatic fever alone. This implicates the basal ganglia in pathophysiology of OCD.

强迫症（ODD）现在被认为是一种常见的疾病 精神障碍，大约有 400 万人发生 仅此一个国家。 在青少年中，患病率可能是一种 百分比。 18 名儿童期发病的成年人的正电子发射断层扫描 强迫症表现出前扣带回和右扣带回的最显着增加 前额叶区域。 这种增加与焦虑状态相关 扫描期间，强迫症的严重程度以及临床反应 氯米帕明。 五十一名儿童和青少年参加了一项正在进行的 氯米帕明 (CMI) 和 去甲基丙咪嗪（DMI）。 DMI 实际上没有任何好处，而 70% 的 OC 受试者至少从 CMI 获得一些帮助。 拔毛癖（拔毛）似乎也对 CMI 有反应。 与 DMI 进行了两次单盲比较和七次双盲比较 已经完成，结果比强迫症更显着。 患有西德纳姆舞蹈病的青少年的患病率明显更高 强迫症的发生率高于仅患有风湿热的对照组。 这 暗示基底神经节与强迫症的病理生理学有关。