TREATMENT OF OBSESSIONAL CHILDREN AND ADOLESCENTS WITH CLOMIPRAMINE

用氯米帕明治疗强迫症儿童和青少年

• 批准号: 3944615
• 负责人: J L RAPOPORT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944615
• 关键词: adolescence (12-20); antidepressants; anxiety; basal ganglia; blood chemistry; cerebrospinal fluid; child mental disorders; computed axial tomography; depression; human subject; human therapy evaluation; imipramine; longitudinal human study; mental disorder chemotherapy; mental health epidemiology; neuropsychological tests; obsessive compulsive disorder; positron emission tomography; psychobiology; serotonin

Obsessive Compulsive Disorder (OCD) is now recognized as a common mental disorder, occurring in perhaps three million people in this country alone. In adolescents, the prevalence maybe as high as one percent. Follow-up studies in our Branch show a chronic course for the disorder with increasing severity of depression and anxiety over time. Clomipramine has a highly specific beneficial effect on obsessions while Desmethylimipramine (DMI) another tricyclic antidepressant did not differ from placebo. New studies with brain imaging (PET and CT scan), as well as a survey of patients with Sydenham's chorea, implicate abnormalities in the basal ganglia while spinal fluid studies show that low concentration of CSF 5-HIAA, the major serotonin metabolite, is associated with more severe OCD.

强迫症（OCD）现在被认为是一种 常见的精神障碍，大约有三百万人发生 独自生活在这个国家的人们。 在青少年中，患病率 也许高达百分之一。 我们分行的后续研究表明， 抑郁和焦虑的严重程度不断增加的疾病 时间。 氯米帕明具有高度特异性的有益作用 痴迷，而去甲基丙咪嗪（DMI）另一种三环 抗抑郁药与安慰剂没有差异。 脑成像（PET 和 CT 扫描）的新研究以及 对西德纳姆舞蹈病患者的调查表明 脊髓液研究显示基底神经节异常 低浓度的 CSF 5-HIAA（主要血清素） 代谢物，与更严重的强迫症有关。