TREATMENT OF OBSESSIONAL CHILDREN AND ADOLESCENTS WITH CHLORIMIPRAMINE

用氯丙咪嗪治疗强迫症儿童和青少年

• 批准号: 3968406
• 负责人: J L RAPOPORT
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968406
• 关键词: adolescence (12-20); antidepressants; blood chemistry; child mental disorders; computed axial tomography; depression; human subject; human therapy evaluation; imipramine; longitudinal human study; mental disorder chemotherapy; mental health epidemiology; neuropsychological tests; obsessive compulsive disorder; psychobiology; serotonin; sleep

Obsessive Compulsive Disorder has fascinated clinicians for hundreds of years, but because of the high proportion (30-40%) of cases with childhood onset, the disorder holds particular interest for child psychiatrists. Moreover, unlike depression and schizophrenia, the disorder appears in virtually identical form in children to that in adults. New information derived from epidemiological, pharmacological and clinical descriptive studies, from studies of related disorders, and from a prospective study of 30 children with severe primary obsessive compulsive disorder, suggest that the disorder is considerably more common than had been thought and reaffirm intriguing neurological links, and severe morbidity of this condition if untreated.

强迫症让临床医生着迷了数百年 年，但由于儿童期病例比例很高（30-40%） 这种疾病一开始就引起了儿童精神病学家的特别关注。 此外，与抑郁症和精神分裂症不同，这种疾病出现在 儿童的形式与成人的形式几乎相同。 来自流行病学、药理学和临床的新信息 描述性研究，来自相关疾病的研究，以及来自 30名严重原发性强迫症儿童的前瞻性研究 表明这种疾病比以前更常见 被认为并重申了有趣的神经学联系，以及严重的 如果不治疗，这种情况的发病率。