HORMONE RHYTHMS: METABOLIC SIGNIFICANCE IN DEPRESSION

激素节律：抑郁症中的代谢意义

• 批准号: 3375051
• 负责人: Robert T. Rubin
• 金额: $ 3.66万
• 依托单位: LOS ANGELES COUNTY HARBOR-UCLA MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-12-01 至 1991-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3375051
• 关键词: adolescence (12-20); adrenocorticotropic hormone; adult human (21+); antidepressants; blood chemistry; circadian rhythms; clinical depression; corticotropin releasing factor; cortisol; dexamethasone suppression test; disease /disorder classification; electroconvulsive therapy; endocrine pharmacology; hormone regulation /control mechanism; human subject; hypothalamus; laboratory rabbit; magnetic resonance imaging; major depression; neuroendocrine system; psychobiology; radioimmunoassay; secretion; thyrotropin releasing hormone

This is a study of the neuroendocrinology of severe endogenous depression, including anterior pituitary hormone secretion patterns, their regulation of peripheral steroid hormones, and the integrity of their control mechanisms as reflected by responses to pertubation tests including thyrotropin releasing hormone, luteinizing hormone releasing hormone, and dexamethasone suppression. Both male and female endogenously depressed patients are being studied under a three day protocol with frequent blood sampling being done for the elucidation of multiple hormone secretion patterns. The patients are studied after one week of hospitalization before any treatment, after one month of tricyclic antidepressant medication of ECT, and several months following discontinuation of treatment. The patients are diagnosed according to the Research Diagnostic Criteria, and psychological ratings for degree of depression are performed at each stage of the patients' illnesses.

这是一项关于严重内源性抑郁症的神经内分泌学的研究， 包括垂体前叶激素的分泌模式及其调节 外周类固醇激素及其控制机制的完整性 通过对微扰测试的反应（包括促甲状腺素释放）来反映 激素、黄体生成素释放激素和地塞米松抑制。 男性和女性内源性抑郁症患者都正在接受一项研究 为期三天的方案，经常进行血液采样以进行阐明 多种激素分泌模式。 一周后对患者进行研究 接受任何治疗前、三环类药物一个月后住院的时间 ECT 抗抑郁药物以及停药后几个月 的治疗。 患者根据研究诊断进行诊断 抑郁程度的标准和心理评级在 患者疾病的各个阶段。