ANDROGEN EXCESS DISORDER

雄激素过多症

• 批准号: 6636729
• 负责人: Ricardo Azziz
• 金额: $ 9万
• 依托单位: CEDARS-SINAI MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-04-05 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6636729
• 关键词: African American; adolescence (12-20); adrenal disorder; adrenocorticotropic hormone; age difference; androgens; caucasian American; clinical research; disease /disorder etiology; family genetics; female; health care personnel education; hormone regulation /control mechanism; human middle age (35-64); human puberty; human subject; medical outreach /case finding; physicians; polycystic ovary syndrome; postmenopause; racial /ethnic difference; role model; training; women's health; young adult human (21-34)

DESCRIPTION (Adapted from applicant's description): As the health care delivery landscape has changed, academic medical centers have begun to demand from their faculty a progressive increase in the time dedicated to revenue-generating patient care. In effect, this has resulted in a reduction in the amount of time dedicated to clinical investigation and the mentoring of beginning investigators. While the applicant (i.e., the Candidate) has had extensive experience in both patient-oriented research (studying androgen excess disorders) and the mentoring of beginning clinical investigators (M.D. clinical, research and Postdoctoral Fellows; undergraduate, graduate and medical students; and residents), the need for increased patient care revenue has begun to erode these abilities. The Candidate now requests additional salary support to continue and expand these investigative and teaching efforts, and to fund some the students' didactic expenses. A mentoring plan is proposed with the broad goals of producing a physician with the clinical, laboratory, and intellectual skills necessary to develop into an accomplished academician, teacher and independent clinical researcher. The specific training objectives include: i) selection and design of a clinical research proposal; ii) evaluation of existing knowledge; iii) the recruitment, study and retention of study subjects; iv) data analysis; v) the performance, application and trouble-shooting of various in vivo dynamic tests; vi) the performance, application and quality control of basic laboratory techniques; manuscript preparation and submission; vii) grant writing; and viii) teaching, lecturing, and preparation of presentations. An Advisory Committee is proposed to assist in assessing potential candidates for mentoring, and monitoring the students' progress. The candidate's research, also to be used for mentoring, is supported by NIH grant 2R01-HD29364-05A1 (Adrenal Androgen [AA] Excess in the Polycystic Ovary Syndrome (PCOS]). The study has the long-term objective of elucidating the etiology of AA excess in the genesis of the PCOS. The specific aims are to determine: i) the prevalence of AA excess in PCOS, using age/race specific normative limits for AA levels; ii) the long-term within-subject variability of AA levels, and their response to ACTH stimulation, in patients with PCOS and normal women; iii) the relative prevalence of the CYPI7 alleles in PCOS patients w/ and w/o AA excess, and in controls; and iv) the heritability of AA levels, and their response to ACTH stimulation, in PCOS w/ and w/o AA excess, and controls. The institution has committed to releasing the Candidate from other duties in order for him to dedicate at least 50% of his time to the research and mentoring activities.

描述（根据申请人的描述改编）：作为医疗保健 交付格局已经改变，学术医疗中心已经开始 教师要求逐步增加专门用于教学的时间 创收的患者护理。实际上，这导致了减少 致力于临床研究和指导的时间 初任调查员。虽然申请人（即候选人）已经 在以患者为导向的研究（研究雄激素 过度疾病）和对初级临床研究人员的指导（M.D. 临床、研究和博士后研究员；本科生、研究生和 医学生；和居民），需要增加患者护理收入 已经开始侵蚀这些能力。候选人现在要求额外的 继续和扩大这些研究和教学的工资支持 努力，并资助一些学生的教学费用。辅导计划是 提出的广泛目标是培养一名具有临床、 实验室和发展成为有成就的人所必需的智力技能 院士、教师、独立临床研究员。具体的 培训目标包括： i) 临床研究的选择和设计 提议; ii) 现有知识的评估； iii) 招募、考察 和保留学习科目； iv) 数据分析； v) 性能， 各种体内动态测试的应用及故障排除；六） 基本实验室技术的性能、应用和质量控制； 稿件准备和提交； vii) 拨款写作；八）教学， 讲授和准备演讲。建议成立咨询委员会 协助评估潜在的指导候选人，并监督 学生的进步。候选人的研究也可用于指导， 得到 NIH 拨款 2R01-HD29364-05A1（肾上腺雄激素 [AA] 过量）的支持 多囊卵巢综合症（PCOS]）。该研究具有长期目标 阐明 PCOS 发生过程中 AA 过量的病因。这 具体目标是确定： i) PCOS 中 AA 过量的患病率，使用 AA 水平的年龄/种族特定规范限制； ii) 长期 AA 水平的受试者内变异性及其对 ACTH 的反应 对 PCOS 患者和正常女性进行刺激； iii) 亲属 CYPI7 等位基因在有和没有 AA 过量的 PCOS 患者中的患病率，以及 控制； iv) AA 水平的遗传性及其对 ACTH 的反应 刺激，在 PCOS 中，有和没有 AA 过量，以及对照。该机构有 承诺免除候选人的其他职责，以便他能够 至少 50% 的时间用于研究和指导活动。