ANDROGEN EXCESS DISORDER

雄激素过多症

基本信息

批准号：
6387368
负责人：
Ricardo Azziz
金额：
$ 8.9万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-04-05 至 2005-03-31
项目状态：
已结题

项目摘要

DESCRIPTION (Adapted from applicant's description): As the health care delivery landscape has changed, academic medical centers have begun to demand from their faculty a progressive increase in the time dedicated to revenue-generating patient care. In effect, this has resulted in a reduction in the amount of time dedicated to clinical investigation and the mentoring of beginning investigators. While the applicant (i.e., the Candidate) has had extensive experience in both patient-oriented research (studying androgen excess disorders) and the mentoring of beginning clinical investigators (M.D. clinical, research and Postdoctoral Fellows; undergraduate, graduate and medical students; and residents), the need for increased patient care revenue has begun to erode these abilities. The Candidate now requests additional salary support to continue and expand these investigative and teaching efforts, and to fund some the students' didactic expenses. A mentoring plan is proposed with the broad goals of producing a physician with the clinical, laboratory, and intellectual skills necessary to develop into an accomplished academician, teacher and independent clinical researcher. The specific training objectives include: i) selection and design of a clinical research proposal; ii) evaluation of existing knowledge; iii) the recruitment, study and retention of study subjects; iv) data analysis; v) the performance, application and trouble-shooting of various in vivo dynamic tests; vi) the performance, application and quality control of basic laboratory techniques; manuscript preparation and submission; vii) grant writing; and viii) teaching, lecturing, and preparation of presentations. An Advisory Committee is proposed to assist in assessing potential candidates for mentoring, and monitoring the students' progress. The candidate's research, also to be used for mentoring, is supported by NIH grant 2R01-HD29364-05A1 (Adrenal Androgen [AA] Excess in the Polycystic Ovary Syndrome (PCOS]). The study has the long-term objective of elucidating the etiology of AA excess in the genesis of the PCOS. The specific aims are to determine: i) the prevalence of AA excess in PCOS, using age/race specific normative limits for AA levels; ii) the long-term within-subject variability of AA levels, and their response to ACTH stimulation, in patients with PCOS and normal women; iii) the relative prevalence of the CYPI7 alleles in PCOS patients w/ and w/o AA excess, and in controls; and iv) the heritability of AA levels, and their response to ACTH stimulation, in PCOS w/ and w/o AA excess, and controls. The institution has committed to releasing the Candidate from other duties in order for him to dedicate at least 50% of his time to the research and mentoring activities.

描述（根据申请人的描述改编）：作为医疗保健交付格局已经改变，学术医疗中心已经开始教师要求逐步增加专门用于教学的时间创收的患者护理。实际上，这导致了减少致力于临床研究和指导的时间初任调查员。虽然申请人（即候选人）已经在以患者为导向的研究（研究雄激素过度疾病）和对初级临床研究人员的指导（M.D. 临床、研究和博士后研究员；本科生、研究生和医学生；和居民），需要增加患者护理收入已经开始侵蚀这些能力。候选人现在要求额外的继续和扩大这些研究和教学的工资支持努力，并资助一些学生的教学费用。辅导计划是提出的广泛目标是培养一名具有临床、实验室和发展成为有成就的人所必需的智力技能院士、教师、独立临床研究员。具体的培训目标包括： i) 临床研究的选择和设计提议; ii) 现有知识的评估； iii) 招募、考察和保留学习科目； iv) 数据分析； v) 性能，各种体内动态测试的应用及故障排除；六）基本实验室技术的性能、应用和质量控制；稿件准备和提交； vii) 拨款写作；八）教学，讲授和准备演讲。建议成立咨询委员会协助评估潜在的指导候选人，并监督学生的进步。候选人的研究也可用于指导，得到 NIH 拨款 2R01-HD29364-05A1（肾上腺雄激素 [AA] 过量）的支持多囊卵巢综合症（PCOS]）。该研究具有长期目标阐明 PCOS 发生过程中 AA 过量的病因。这具体目标是确定： i) PCOS 中 AA 过量的患病率，使用 AA 水平的年龄/种族特定规范限制； ii) 长期 AA 水平的受试者内变异性及其对 ACTH 的反应对 PCOS 患者和正常女性进行刺激； iii) 亲属 CYPI7 等位基因在有和没有 AA 过量的 PCOS 患者中的患病率，以及控制； iv) AA 水平的遗传性及其对 ACTH 的反应刺激，在 PCOS 中，有和没有 AA 过量，以及对照。该机构有承诺免除候选人的其他职责，以便他能够至少 50% 的时间用于研究和指导活动。