CORE--ANIMAL

核心--动物

• 批准号: 6098434
• 负责人: STANLEY B PRUSINER
• 金额: $ 23.85万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-04-01 至 2000-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6098434
• 关键词: animal breeding; animal care; animal colony; bioassay; biomedical facility; genetically modified animals; hamsters; immunologic assay /test; laboratory mouse; laboratory rabbit; neural degeneration; prions; protein purification; scrapie; tissue /cell preparation

The function of the Animal Core is to produce and maintain all of the animals required for the scientific projects for this and several other program project grants. The specific services of the Animal Core personnel include: 1) Production of transgenic and knockout mice; 2) Production of large volumes of scrapie-infected hamster brains for purification; 3) Performing experimental inoculations, neurologic scoring of animals, data collection, and tissue collections; 4) Providing transportation of animals and tissue between the laboratory and the animal facility; 5) Production of antibodies in mice and rabbits for experimental use; and 6) Providing all animal care and veterinary care. The Animal Core operates in two purpose-built facilities in the Hunters Point area of San Francisco, approximately 12 miles from the main UCSF campus. Its' activities are directed by Dr. Prusiner and Dr. Marilyn Torchia, a laboratory animal veterinarian. Building 830B is a new nine room transgenic mouse breeding facility which just recently opened for our large breeding colony. Building 830 houses all the experimental animals in 19 rooms, under BSL 1 and 2 bio-containment.

动物核心的功能是产生和维持所有的 该项目和其他几个科学项目所需的动物 计划项目补助金。 Animal Core的具体服务 人员包括： 1）转基因、基因敲除小鼠的生产； 2） 生产大量感染痒病的仓鼠大脑 纯化; 3) 进行实验接种、神经评分 动物、数据收集和组织收集； 4) 提供 实验室和实验室之间的动物和组织运输 动物设施； 5) 在小鼠和兔中生产抗体 实验使用； 6) 提供所有动物护理和兽医护理。 动物核心在猎人区的两个专用设施中运营 旧金山的点区，距加州大学旧金山分校主校区约 12 英里 校园。 其活动由 Prusiner 博士和 Marilyn 博士指导 Torchia，一名实验动物兽医。 830B号楼是新九号楼 最近刚刚开放的室内转基因小鼠饲养设施 我们的大型繁殖群。 830号楼容纳了所有的实验 19 个房间内的动物，处于 BSL 1 和 2 生物安全措施之下。