HIGH-SPEED MRI FOR TUMOR INTERVENTIONS

用于肿瘤干预的高速 MRI

• 批准号: 6194302
• 负责人: ALBERT MACOVSKI
• 金额: $ 30.94万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-04 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6194302
• 关键词: abdomen neoplasm; angiography; bioimaging /biomedical imaging; clinical research; diagnosis design /evaluation; fluoroscopy; human subject; image processing; magnetic resonance imaging; method development; neoplasm /cancer diagnosis; phantom model; ultrasonography

DESCRIPTION (Adapted from Applicant's Abstract): This application is a competing renewal. The original project concerned new fast magnetic resonance imaging (MRI) techniques for improved diagnosis of abdominal tumors. Significant progress was made in developing several fast-scan methods that produce high-quality T2-weighted abdominal images in a breath-hold. The focus of this competing renewal is on new MR methods that take the next step beyond tumor detection---the guidance of tumor biopsies and other interventional procedures using MR. The project title has been modified to reflect this change in focus. The aims of this project are to 1) design and implement a real-time, interactive (RTI) MRI system tailored for interventional procedures, 2) develop and integrate into the RTI system new sequences that provide useful image contrast for interventional procedures; and 3) evaluate this new MR interventional system on phantoms and patients. The research plan includes substantial technical development of a versatile RTI MRI platform, studies of improved MR acquisition methods (e.g., steady-state free precession, fast spin echo, and color flow), and systematic tests to validate the performance of the resultant system. A research team with extensive technical and clinical expertise has been assembled for this project. This expertise, along with the state-of-the-art scanners available, make Stanford University an ideal environment to carry out this project.

描述（改编自申请人的摘要）：该申请是 竞争更新。最初的项目涉及新型快速磁共振 成像（MRI）技术可改善腹部肿瘤的诊断。 在开发几种快速扫描方法方面取得了重大进展 屏气时生成高质量的 T2 加权腹部图像。焦点 这种竞争性更新的重点在于新的 MR 方法，该方法迈出了下一步 肿瘤检测——指导肿瘤活检及其他介入治疗 使用 MR 的程序。项目标题已修改以反映这一变化 焦点。该项目的目标是 1）设计和实现实时、 专为介入手术量身定制的交互式 (RTI) MRI 系统，2) 开发 并将新序列集成到 RTI 系统中，提供有用的图像 介入手术的对比； 3) 评估这个新的 MR 体模和患者的介入系统。研究计划包括 多功能 RTI MRI 平台的实质性技术开发、研究 改进的 MR 采集方法（例如稳态自由进动、快速自旋 回声和颜色流），以及系统测试来验证性能 由此产生的系统。具有丰富技术和临床经验的研究团队 该项目已汇集了专业知识。这种专业知识以及 斯坦福大学拥有最先进的扫描仪，成为理想的大学 开展本项目的环境。