Low-Cost, High-Quality Prepolarized MRI Head Scanner

低成本、高质量预极化 MRI 头部扫描仪

• 批准号: 6478568
• 负责人: ALBERT MACOVSKI
• 金额: $ 36.19万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6478568
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain imaging /visualization /scanning; clinical research; cost effectiveness; head; human subject; image enhancement; magnetic resonance imaging; phantom model

DESCRIPTION (provided by applicant): In May of 1999, we were awarded an R21 grant to study and develop a prototype hardware configuration for low-cost magnetic resonance imaging called Prepolarized MRI. During the R21 support, we succeeded in building a Prepolarized MRI scanner for less than $30,000 and we succeeded in acquiring in vivo human hand images. The image quality is roughly comparable to a 0.2 T conventional MRI scanner and is rapidly improving. This R33 application is in response to the Development of Novel Technologies for In Vivo Imaging (PAR-07- 707) Phased Innovation Initiative. Here we propose to extend the technology development initiated in the R21 grant to develop an ultra-low-cost prepolarized MRI head scanner. Prepolarized MRI uses two pulsed magnetic fields. First a strong but inhomogeneous polarizing magnet is pulsed on to polarize hydrogen. This field is turned off and a very low field MRI acquisition follows. A prepolarized MRI scanner with a 0.5 T polarizing field should obtain the image quality of a conventional 0.5 T MRI scanner for a small fraction of the capital cost of a conventional MRI scanner. Here we propose to build a 0.5 T polarizing magnet and a low-field imaging MRI scanner for head imaging. We also plan to develop all the standard imaging pulse sequences that are currently used for detecting and following brain tumors. We plan to investigate the new contrast mechanisms that prepolarized MRI can offer. And finally, we plan to do a small study comparing image quality on a conventional 0.5 T GE MRI scanner. The results of this study will provide feedback for optimizing both the hardware and pulse sequences.

描述（由申请人提供）： 1999年5月，我们获得了R21赠款，以研究和开发原型 低成本磁共振成像的硬件配置称为 prodallized MRI。在R21支持期间，我们成功建立了 优先化的MRI扫描仪不到30,000美元，我们成功地收购了 体内人体图像。图像质量与0.2 T大致相当 常规的MRI扫描仪正在迅速改善。此R33应用程序在 对体内成像的新技术发展的反应（PAR-07-- 707）分阶段创新计划。在这里我们建议扩展技术 在R21赠款中发起的开发以开发超低成本 预算力的MRI头扫描仪。 预算力的MRI使用两个脉冲磁场。首先是强大但 不均匀的偏振磁体脉冲以极化氢。这个领域 被关闭，随后是非常低的现场MRI收购。一个预算力的MRI 具有0.5 T偏振场的扫描仪应获得A的图像质量 常规0.5 T MRI扫描仪，仅占A的一小部分资本成本 常规的MRI扫描仪。在这里，我们建议建造0.5 t偏振磁铁 以及用于头部成像的低场成像MRI扫描仪。我们还计划发展 当前用于检测的所有标准成像脉冲序列 并遵循脑肿瘤。我们计划研究新的对比机制 该预算力的MRI可以提供。最后，我们计划进行小型研究 比较常规0.5 T GE MRI扫描仪上的图像质量。结果 这项研究将提供优化硬件和脉冲的反馈 序列。