DEVELOPMENT OF IMPROVED MRI TECHNIQUES FOR CARTILAGE INJ

改进软骨注射 MRI 技术的开发

• 批准号: 2850584
• 负责人: ALBERT MACOVSKI
• 金额: $ 23.9万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-17 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2850584
• 关键词: bioimaging /biomedical imaging; cartilage; cartilage metabolism; clinical research; human subject; injury; knee; magnetic resonance imaging; method development; orthopedics; osteoarthritis; pathologic process

DESCRIPTION (Adapted from Applicant's Description): Cartilage injury leading to osteoarthritis is a leading cause of disability in young people. Osteoarthritis, either based on cartilage injury or degeneration, is a leading cause of disability in the United States. Over the last several decades, much progress has been made in understanding cartilage injury and repair. MRI, with its unique ability to non-invasively image and characterize soft tissue, has shown promise in imaging cartilage. The goal of this proposal is to develop new MRI techniques to assess areas of cartilage damage and repair. Beyond simply demonstrating the morphology of an area of cartilage damage or repair, the investigators will use MRI to characterize the type of tissue present, which has implications about the prognosis and success of the repair. The proposal consists of three components. One is the development of the basic MR imaging technology. This will occur in parallel with the second component, i.e. studies of patients undergoing total knee replacement surgery. This will allow the assessment of the new imaging methods on the wide range of degenerative cartilage conditions typically present in such patients. Finally, a study will be performed to test these new methods in assessing and characterizing cartilage in patients who have had cartilage repair therapy three years previously. MRI holds much promise for assessment of cartilage injury and repair. Emerging therapies for cartilage injury require accurate, non-invasive assessment of repair tissue morphology and content. Development of new techniques to do this has the potential to allow rapid assessment of the effectiveness of these new therapies.

描述（根据申请人的描述改编）：软骨伤害领先 骨关节炎是年轻人残疾的主要原因。 骨关节炎是基于软骨损伤或变性的，是领先的 美国的残疾原因。在过去的几十年中，很多 在理解软骨损伤和修复方面取得了进展。 MRI，与 它独特的非侵入性图像和表征软组织的能力，具有 在成像软骨中显示出承诺。该提议的目的是发展 新的MRI技术评估软骨损坏和修复区域。超过 只需证明软骨损坏或修复区域的形态， 研究人员将使用MRI来表征存在的组织类型， 这对维修的预后和成功具有影响。 该提案由三个组成部分组成。一个是基本的发展 先生成像技术。这将与第二个组件并行发生 即对接受全膝关节置换手术的患者的研究。这会 允许评估广泛的新成像方法 此类患者通常存在退化性软骨条件。最后， 将进行一项研究以测试这些新方法在评估和 表征有软骨修复疗法的患者的软骨 三年前。 MRI对软骨损伤和维修的评估有很大的希望。新兴 软骨损伤的疗法需要准确，无创的评估 修复组织形态和含量。开发新技术来做到这一点 有可能快速评估这些新的有效性 疗法。