REALISTIC NUMERICAL MODELS OF BRAIN ELECTRICAL CURRENTS

脑电流的现实数值模型

• 批准号: 6142619
• 负责人: Richard E. Greenblatt
• 金额: $ 10.42万
• 依托单位: SOURCE SIGNAL IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6142619
• 关键词: bioimaging /biomedical imaging; brain electrical activity; computer program /software; electroencephalography; evoked potentials; human data; magnetic resonance imaging; magnetoencephalography; mathematical model; model design /development

Functional imaging techniques are important to brain researchers and clinicians alike because many phenomena cannot he observed by anatomical techniques alone. Among functional imaging methods, only magneto- and electro-encephalography (MEG, EEG, or jointly M/EEG) can noninvasively resolve events with a millisecond time scale. The aim of this work is the development, validation, and commercialization of a detailed, realistic model of electrical current flow in the head, the currents originating from sources within the brain, and measured electrically and/or magnetically on or near the surface of the scalp. 3D finite element models of individual heads will be constructed with the aid of magnetic resonance imaging (MRI). The finite element method provides the needed flexibility for modeling an asymmetric, anisotropic, and inhomogeneous medium like the head. The algorithms will he incorporated into prototype software, and the software validated with both simulated and experimental data. The software will comprise a realistic modeling module of our EMSE suite, our PC/Windows-based program suite for analysis and display. The algorithms and resulting software may be used to study both normal brain function, such as measurements in cognitive neuroscience which may he studied with evoked response/event related potentials or spontaneous EEG, and in diseases of the brain, such as the epilepsies, where precise spatial and temporal resolution may be of value for diagnosis and presurgical evaluation. PROPOSED COMMERCIAL APPLICATIONS: The technique which we propose is a non-invasive, non-radiological and relatively low cost addition to existing EEG, MEG and MRI systems, and provides information which is not currently available from these systems independently. The resulting software will have direct application in clinical and cognitive neuroscience research. If clinical value is demonstrated, systems based on this methodology may find applications in the areas of psychiatry, neurology and psychology.

功能成像技术对大脑研究人员和临床医生都很重要，因为仅通过解剖技术观察到许多现象。在功能成像方法中，仅磁和电脑摄影（MEG，EEG或共同M/EEG）可以以毫秒的时间尺度非侵入性地解决事件。这项工作的目的是对头部电流流的详细，现实模型的开发，验证和商业化，源自大脑内部源的电流，并在头皮表面上或附近进行电气和/或磁性测量。将借助磁共振成像（MRI）构建单个头部的3D有限元模型。有限元方法提供了建模不对称，各向异性和不均匀培养基（如头部）所需的灵活性。他将将算法合并到原型软件中，并用模拟和实验数据验证该软件。该软件将包括我们EMSE Suite的现实建模模块，即我们的基于PC/Windows的程序套件，用于分析和显示。算法和所得软件可用于研究正常的大脑功能，例如他可以通过诱发的反应/事件相关的潜力或自发的EEG进行认知神经科学的测量，以及大脑疾病（例如癫痫病），例如癫痫病，在精确的空间和时间分辨率上可能具有诊断和保护性评估的价值。拟议的商业应用：我们提出的技术是一种非侵入性，非放射学且相对较低的成本增加现有的EEG，MEG和MRI系统，并提供了目前独立从这些系统中获得的信息。所得软件将直接应用于临床和认知神经科学研究。如果证明临床价值，基于此方法的系统可能会在精神病学，神经病学和心理学领域中找到应用。