Electrocorticography Visualization and Analysis Software

皮质电图可视化和分析软件

• 批准号: 6834223
• 负责人: Richard E. Greenblatt
• 金额: $ 10万
• 依托单位: SOURCE SIGNAL IMAGING, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6834223
• 关键词: bioimaging /biomedical imaging; brain electrical activity; brain imaging /visualization /scanning; clinical research; computed axial tomography; computer data analysis; computer program /software; computer system design /evaluation; electrocorticography; electrodes; epilepsy; functional magnetic resonance imaging; human subject; image guided surgery /therapy; magnetic resonance imaging; patient oriented research; positron emission tomography; single photon emission computed tomography; three dimensional imaging /topography

DESCRIPTION (provided by applicant): The epilepsies are a family of disorders of brain dynamics. Epilepsy patients are susceptible to seizures (changes in sensation, awareness, or behavior caused by brief electrical disturbances in the brain). Often, the electrical disturbances originate from a "focus" or "epileptogenic zone" in part of the brain, from which the disturbances are propagated to other parts of the brain. Epilepsy affects approximately 2.5 million persons in the United States, and over 50 million persons worldwide, and 150,000 to 200,000 new cases occur annually in the U.S. Although most epilepsy patients can control their seizures with the use of antiepileptic drugs, between 20% to 25% of patients cannot bring their seizures under control using drug therapy. Many patients with pharmacologically intractable seizures can eliminate their disability largely or completely by neurosurgical intervention, which typically involves resection of tissue in the epileptogenic zone to prevent the spread of electrical disturbances. Candidates for epilepsy surgery are generally evaluated first with scalp EEG telemetry. In approximately 20% of cases, however, intracranial monitoring with brain surface (ElectroCorticoGraphy, or ECoG) and/or depth electrodes is required to determine the site(s) of seizure onset. We propose to develop software tools that will aid the clinician in the identification of the epileptogenic zone from ECoG data, through the multimodal integration of ECoG/depth electrode data with structural (sMRI) and functional (fMRI, PET, SPECT) imaging data, visualization of ECoG data, both in space and time, and analysis of ECoG data. During Phase I, we will design, implement, and validate software to integrate the visualization of ECoG electrode locations on a subject-specific brain surface representation obtained from MRI data, and visualize ECoG activity patterns in both space and time. A principal design objective is the creation of a software tool that can be used by a trained technician to produce a reliable visualization with less than 1 hour of preparation time.

描述（由申请人提供）：癫痫病是大脑动态疾病的家族。癫痫患者容易受到癫痫发作（感觉，意识的变化或由大脑短暂的电动障碍引起的）。 通常，电干扰源于大脑的一部分“焦点”或“癫痫发作区”，从中，扰动传播到大脑的其他部位。癫痫在美国影响约250万人，全球超过5000万人，每年在美国发生150,000至200,000例新病例，尽管大多数癫痫患者可以通过使用抗癫痫药物来控制其癫痫发作，而使用抗癫痫药，20％至25％的患者无法控制使用药物治疗。许多具有药理学性疾病的患者可以通过神经外科干预大部分或完全消除其残疾，这通常涉及在癫痫发作区切除组织以防止电动障碍的扩散。通常首先使用头皮脑电图评估癫痫手术的候选者。但是，在大约20％的情况下，需要用脑表表面（电皮质学或ECOG）和/或深度电极进行颅内监测才能确定癫痫发作的位点。 我们建议开发软件工具，以通过ECOG/DEPTH电极数据与结构（SMRI）和功能（FMRI，PET，Spoct）成像，ECOG数据的可视化以及ECOG数据分析的ECOG数据的可视化以及ECOG数据的可视化以及ECOG数据的可视化，从而帮助临床医生从ECOG数据鉴定癫痫发作区。在第一阶段，我们将设计，实现和验证软件，以在从MRI数据获得的主题特定的大脑表面表示上集成ECOG电极位置的可视化，并可视化时空中的ECOG活动模式。 主要设计目标是创建软件工具，该工具可以由训练有素的技术人员使用，以制作不到1小时的准备时间的可靠可视化。