MONKEY MODEL FOR INFANTILE APHAKIA/AMBLYOPIA TREATMENT

用于婴儿无晶状体/弱视治疗的猴子模型

基本信息

批准号：
2888190
负责人：
RONALD G BOOTHE
金额：
$ 29.22万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-08-01 至 2001-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2888190
关键词：
Primates amblyopia binocular vision brain mapping cataract contact lens developmental neurobiology disease /disorder model evoked potentials infant animal neural plasticity neuroanatomy nonhuman therapy evaluation visual deprivation visual perception visual stimulus

项目摘要

DESCRIPTION: The aphakic amblyopia that develops in children after the removal of a cataract is particularly difficult to treat. One reason for the recalcitrance to respond to treatment is the early onset of the deprivation: the developing infant's brain has little opportunity to experience the normal binocular stimulation that is needed for proper development of the visual system. The objectives of this project are to understand the neural bases for this and related disorders and, ultimately, to design treatments for amblyopia that are based on sound scientific knowledge. Systematic studies of infant monkeys with extended wear contact lenses that simulate certain aspects of the visual deprivation experienced by children with an early onset infantile cataract corroborate the clinical findings in children that no schedules of patching, even those that maintain relatively good acuity, are successful at maintaining normal binocular function in these children. The proposed studies are designed specifically to better understand the neural mechanisms involved in the loss of binocular function. The primary probe will be a neurological deficit involving motion processing that is linked to loss of binocular function following neonatal deprivation. A combination of behavioral, electrophysiological and anatomical methods will be used to correlate the behavioral deficits to alterations in specific neural subsystems of the brain and to test specific hypotheses about the underlying neurodevelopmental mechanisms. The results will provide direct information about alterations in the central visual pathways of monkeys following early visual deprivation that can also be extrapolated to human infants with aphakic amblyopia, because of the close similarities between this condition as it occurs naturally in humans and experimentally in our monkeys.

描述：在儿童之后在儿童中发展的蚜虫弱视去除白内障特别困难。一个原因为了使顽固症对治疗做出反应是早期发作剥夺：发育中的婴儿的大脑几乎没有机会体验正常的双眼刺激视觉系统的开发。这个项目的目标是了解有关此疾病和相关疾病的神经碱，以及最终，设计基于声音的弱视的治疗方法科学知识。对婴儿猴的系统研究佩戴隐形眼镜，模拟视觉的某些方面早期发病的儿童遭受的剥夺白内障证实了没有时间表的儿童的临床发现修补，甚至那些保持敏锐度相对较好的修补程序，也是成功地维持这些儿童正常的双目功能。拟议的研究专门旨在更好地了解涉及双眼功能的神经机制。这主要探测器将是涉及运动处理的神经缺陷这与新生儿后双眼功能的丧失有关剥夺。行为，电生理和解剖方法将用于将行为缺陷与大脑特定神经子系统的改变并测试关于基本神经发育机制的特定假设。结果将提供有关更改的直接信息早期视觉剥夺后的猴子的中央视觉途径也可以将其推断到患有蚜虫弱视的人类婴儿，由于这种情况之间的相似之处很紧密自然在人类中，在我们的猴子中实验。