TREATMENTS FOR APHAKIC AMBLYOPIA

无晶状体弱视的治疗

• 批准号: 6277514
• 负责人: RONALD G BOOTHE
• 金额: $ 4.16万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 1999-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6277514
• 关键词: Mammalia; Primates; congenital disorders; eye; growth /development; nervous system; psychology

We have reared neonatal monkeys under many different visual conditions and tested their VEP asymmetry to determine what conditions lead to abnormalities. Our emphasis has been on binocularity and its influence on the asymmetry. As one aspect of this search, it has been found that normal neonates, and many adults after abnormal visual development, have directional preferences for visual stimulus motions; i.e., they give better responses for optokinetic nystagmus (OKN) and visually evoked potentials (VEP) in one direction when compared with the opposite direction. We tested whether the asymmetrical VEP responses were because of abnormal eye movements. Our results show that the neonate and abnormally reared monkeys continued to have asymmetrical responses even after their eyes were paralyzed. Therefore, eye movements cannot be the source of the asymmetrical amplitudes of the VEPs, and the visual cortex is at least one possible source controlling asymmetries observed in neona tes and adults reared under abnormal visual inputs.

我们已经在许多不同的视觉上饲养了新生儿猴子 条件并测试其VEP不对称性，以确定什么条件 导致异常。 我们的重点是双向性及其的重点 对不对称的影响。 作为此搜索的一个方面，它一直 发现正常的新生儿和许多成年人异常视觉 开发，具有视觉刺激运动的定向偏好； 即，他们对光（OKN）和 与 相反的方向。 我们测试了不对称的VEP是否 反应是由于眼睛的异常运动。 我们的结果表明 新生儿和异常饲养的猴子继续有 即使眼睛瘫痪后，不对称反应也是如此。 因此，眼动不能成为不对称的来源 VEP的振幅和视觉皮层至少是一种 在Neona TE和成年人中观察到的不对称的来源控制不对称 在异常的视觉输入下。