Cortical basis of binocular depth perception

双目深度知觉的皮质基础

基本信息

批准号：
10681944
负责人：
Aaron W McGee
金额：
$ 39.89万
依托单位：
UNIVERSITY OF LOUISVILLE
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-07-01 至 2028-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10681944
关键词：
Adult Affect Age Amblyopia Attenuated Behavioral Binocular Vision Biological Assay Blindness Calcium Cataract Characteristics Child Childhood Complex Data Depth Perception Development Dimensions Discrimination Disease Disparity Eye Felis catus Foundations Genetic Image Impairment Knowledge Lazy Eyes Measures Mission Monocular Vision Mus Neurons Ocular Dominance Perception Performance Population Primates Property Psychometrics Public Health Rattus Refractive Errors Research Rodent Role Surgical sutures Symptoms Systems Development Task Performances Testing Therapeutic Therapeutic Intervention United States National Institutes of Health Vision Vision Disorders Vision Disparity Visual Visual Acuity Visual Cortex Visual System Visual impairment area striata critical developmental period critical period deprivation designer receptors exclusively activated by designer drugs excitatory neuron experience experimental study extrastriate visual cortex improved in vivo calcium imaging monocular deprivation mouse model neural circuit postnatal response spatial vision stereoscopic targeted treatment timeline tool two photon microscopy vision development

项目摘要

Abstract The functional properties of the visual system are most sensitive to disruptions of normal vision during developmental ‘critical periods’. Interestingly, the critical periods for several functional properties, such as ocular dominance and acuity, overlap during development. Abnormal vision during these overlapping critical periods, because of cataracts or misalignment of the two eyes for example, is the cause of amblyopia. Amblyopia is a prevalent visual disorder in children and can present with any of several visual problems including lower visual acuity and impaired depth perception. Yet, how depth perception is affected by abnormal vision has remained elusive. In the proposed research, we investigate the circuit basis for the development and plasticity of depth perception in the mouse. The development of stereoscopic vision is much slower than other characteristics of vision and relies on complex properties of binocular disparity. Disparity between the eyes is what produces the perception of depth. We will characterize multiple dimensions of its development and plasticity by taking advantage of a natural depth discrimination task that depends on binocular vision. Over this same period, we will measure with two-photon microscopy how complex disparity properties are refined in the visual cortex and area LM (a secondary binocular visual area), as well as how and when they are sensitive to abnormal vision. Understanding the properties of binocular depth perception and the development of those properties will provide a foundation for developing therapeutic approaches to treat developmental visual disorders such as amblyopia that cause stereovision deficits.

抽象的视觉系统的功能特性对正常视力的破坏最敏感发展的“关键时期”。有趣的是，几种功能特性的关键时期，例如眼优势和敏锐度，在开发过程中重叠。在这些重叠的关键时期，异常视力，例如，两只眼睛的白内障或未对准是弱视的原因。儿童中普遍的视觉障碍，可以出现几个视觉问题中的任何一个，包括较低的视觉敏锐度和深度感知受损。然而，深度感知如何受到异常视力的影响难以捉摸。在拟议的研究中，我们研究了深度发展和可塑性的电路基础鼠标的感知。立体视觉的发展比其他特征的其他特征要慢得多视觉和依赖双眼差的复杂特性。眼睛之间的差异是产生的深度感知。我们将通过采取其发展和可塑性的多个维度来表征自然深度歧视任务的优势取决于双眼视力。在同一时期，我们将用两光子显微镜测量如何在视觉皮层和 LM区域（次要双眼视觉区域），以及它们如何以及何时对异常视力敏感。了解双眼深度感知的特性以及这些特性的发展将提供开发治疗性视觉疾病（例如弱视）的治疗方法的基础这会导致立体电视缺陷。