LOW DOSE SCANNING X-RAY SYSTEM FOR CARDIAC ANGIOGRAPHY

用于心脏血管造影的低剂量扫描 X 射线系统

• 批准号: 2839021
• 负责人: MICHAEL S. VAN LYSEL
• 金额: $ 19.31万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-05 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2839021
• 关键词: X ray; angiocardiography; bioimaging /biomedical imaging; biomedical equipment development; clinical research; diagnosis design /evaluation; heart imaging /visualization /scanning; human subject; phantom model; radiation detector; radiation dosage; swine

DESCRIPTION (Adapted from Applicant's Abstract): Fluoroscopically-guided procedures have become a tool in the diagnosis and treatment of coronary artery disease. However, increasing concern is expressed at the high level of x-ray exposure which can be delivered. A low-dose scanning-beam digital x-ray (SBDX) system has been developed to address this problem. The SBDX system uses electronic scanning and a detector array to provide high resolution images at 30 frames/sec. System geometry results in a negligible level of detected scattered radiation. Preliminary results indicate a several fold reduction in patient exposure, with larger patients enjoying the greatest decrease. The goal of this proposal is to validate the SBDX system for the application of diagnostic and interventional cardiac angiography. Five specific aims are proposed: 1) Compare the basic imaging properties (modulation transfer function, detective quantum efficiency, noise power spectrum) of SBDX and a conventional angiographic/interventional image-intensifier-based system; 2) Measure the x-ray exposure reduction provided by SBDX using phantom and porcine models; 3) Validate that the clinically important tasks of coronary angiography and ventriculography can be performed accurately using the SBDX system. This will be performed in a porcine model; 4) Investigate the potential improvements in videodensitometric quantitation algorithms provided by the scatter-free nature of the SBDX images. This will be performed in phantom and porcine models; and 5) Demonstrate in patients that accurate coronary angiographic results can be obtained using SBDX. The successful completion of this research will provide a coronary angiographic/interventional x-ray system with previously unachieved levels of safety without compromising image quality.

描述（改编自申请人的摘要）：荧光镜引导 程序已成为诊断和治疗冠状动脉的工具 动脉疾病。 但是，越来越多的关注点在高水平上表达 可以交付的X射线暴露。 低剂量扫描梁数字 已经开发了X射线（SBDX）系统来解决此问题。 SBDX 系统使用电子扫描和检测器阵列可提供高 分辨率图像30帧/秒。 系统几何形状可忽略不计 检测到的散射辐射水平。 初步结果表明 患者暴露的几点减少，较大的患者享受 最大的减少。 该提议的目的是验证SBDX 应用诊断和介入心脏的系统 血管造影。 提出了五个具体目标：1）比较基本成像 属性（调制转移函数，侦探量子效率， SBDX的噪声功率谱和常规血管造影/介入 基于图像冲突的系统； 2）测量X射线暴露减少 由SBDX使用幻影和猪模型提供； 3）验证 冠状动脉血管造影和心室术的临床重要任务可以 使用SBDX系统准确地执行。 这将在 猪模型； 4）调查潜在的改进 无散射提供的视频测定定量算法 SBDX图像的性质。 这将在幻影和猪中进行 模型； 5）在患者中证明精确的冠状动脉造影 可以使用SBDX获得结果。 成功完成 研究将提供冠状动脉造影/介入X射线系统 以前未能达到的安全水平而不损害图像 质量。