QUANTITATIVE VENTRICULOGRAPHY USING DUAL-ENERGY DSA

使用双能 DSA 进行定量心室造影

• 批准号: 3354637
• 负责人: MICHAEL S. VAN LYSEL
• 金额: $ 18.88万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-04-01 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3354637
• 关键词: angiography; artery stenosis; cardiovascular stress test; clinical biomedical equipment; computer simulation; coronary artery; densitometry; dogs; heart catheterization; heart disorder diagnosis; heart ventricle; mathematical model

Previous applications of digital subtraction angiography (DSA) to the assessment of ventricular function, particularly during exercise, have been limited by cardiac, respiratory, and gross patient motion. Dual-energy DSA, however, is insensitive to motion, and makes DSA imaging readily applicable to cardiac patients. For the first time, dual-energy subtraction is available in a clinical cardiac catheterization laboratory. The purpose of this research is to apply the dual-energy technique to patients with cardiac disease, and quantitatively assess both global and regional left ventricular function during rest and exercise. More specifically, the aims are: Firstly, exploiting the motion immunity of this technique, it is proposed to develop and apply a digital subtraction dual-energy ventriculographic exercise stress test using a right heart catheter. This exercise test will be utilized to assess the functional significance of coronary stenoses at the time of cardiac catheterization. Secondly, a videodensitometric analysis of dual-energy subtraction images is under investigation to test the hypothesis that absolute global left ventricular volumes can be accurately measured independent of geometric assumptions, This will be done using a direct measure of blood iodine concentration. Thirdly, it will be determined whether accurate volume measurements can be made without direct sampling of the blood iodine concentration. Thus, absolute volume determinations may be possible without the need of arterial catheterization. Fourthly, a phase-matched rest/exercise wall motion display is being developed to quantitate regional myocardial function independent of cardiac coordinate systems. Phase- matching refers to the superposition of two images at the same point in the cardiac cycle, one at rest and one during exercise. The results of this research will provide improved methods of assessing the functional significance of coronary stenoses in patients. Furthermore, these techniques have the potential to provide a high resolution outpatient test for coronary artery disease and for the serial assessment of rest and exercise ventricular function in patients with cardiac disease.

数字减法血管造影（DSA）的先前应用 心室功能的评估，特别是在运动过程中 受心脏，呼吸和总体运动的限制。 双能 但是，DSA对运动不敏感，并使DSA容易成像 适用于心脏病患者。 第一次，双能量 减法在临床心脏导管实验室中可用。 这项研究的目的是将双能技术应用于 心脏病患者，并定量评估全球和 休息和运动期间区域左心室功能。 更多的 具体而言，目的是：首先，利用运动免疫力 该技术建议开发和施加数字减法 使用正确心脏的双能心室运动压力测试 导管。 该运动测试将用于评估功能 心脏导管插入术时冠状动脉炎症的重要性。 其次，双能量减法图像的视频测定分析 正在研究以检验绝对全球左派的假设 心室体积可以准确地测量与几何学无关 假设，这将使用直接的血液碘来完成 专注。 第三，将确定是否准确 可以在不直接取样血液碘的情况下进行测量 专注。 因此，可以确定绝对体积 不需要动脉导管插入术。 第四，相匹配 正在开发休息/运动壁运动显示以定量区域 心肌功能与心脏坐标系无关。 阶段- 匹配是指在同一点的两个图像的叠加 心脏周期，一个休息，一个在运动过程中。 结果的结果 研究将提供改进的评估功能的方法 冠状动脉狭窄在患者中的重要性。 此外，这些 技术有可能提供高分辨率的门诊测试 用于冠状动脉疾病以及静止和序列评估 在心脏病患者中运动性心室功能。