Low-Dose Tomosynthetic Interventional System For Quantitative Cardiac Imaging

用于定量心脏成像的低剂量断层合成介入系统

• 批准号: 7754055
• 负责人: MICHAEL S. VAN LYSEL
• 金额: $ 51.2万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7754055
• 关键词: Ablation; Anatomy; Angiography; Area; Arrhythmia; Arts; Atrial Fibrillation; Cardiac; Cardiac Catheterization Procedures; Cardiac ablation; Cardiology; Catheterization; Catheters; Clinical; Coronary Angiography; Coronary Vessels; Coronary artery; Country; Devices; Dimensions; Dose; Elements; Exposure to; Family suidae; Frequencies; Goals; Heart Diseases; Image; Left; Life; Medical Staff; Metric; Morbidity - disease rate; Nature; Noise; Operating System; Outcome; Outcomes Research; Patients; Performance; Procedures; Radiation; Radio; Relative (related person); Resolution; Savings; Scanning; Signal Transduction; Skin; Societies; Stents; Structure; System; Therapeutic; Thick; Time; coronary angioplasty; design; detector; digital; improved; mortality; prototype; tool

DESCRIPTION (provided by applicant): We have produced an interventional cardiac catheterization system (SBDX) which provides 70% of the signal-to-noise ratio (SNR) of coronary angiography with only 15% of the patient skin dose, relative to conventional systems. We propose to modify this system to provide 100% of the SNR of a conventional system at 15% of the patient skin dose. This fluoroscopic system also has a unique ability to locate vessels and interventional devices in 3D at 30 frames/sec. We propose to use this ability to enhance the performance of two important clinical procedures: accurate balloon and stent sizing during coronary angioplasty and treatment of left atrial fibrillation using radio-frequency (RF) catheter ablation. AIM 1 - The increase in SNR will be accomplished by the construction of a new detector of the same design, but 2x greater area. We will demonstrate that we have reached our goal by comparison of image quality metrics and the results of porcine imaging studies on both SBDX and a state of the art conventional system. AIM 2 - We will demonstrate the ability of SBDX to perform accurate vessel and device sizing during the catheterization procedure, so that it may aid the interventionalist in the delivery of therapy. AIM 3 - We will demonstrate the ability of SBDX to aid the electrophysiologist with the localization of cardiac structures by providing real-time 3D catheter tracking and accurate registration of CT and fluoroscopic images during the procedure. Heart disease is a significant cause of morbidity and mortality in our society. Over 500,000 coronary angioplasties and 100,000 RF catheter ablation procedures are performed annually in our country, saving many lives and improving the quality of many more. The successful outcome of this research will provide therapeutic tools which improve the outcomes of these procedures, while dramatically lowering the radiation exposure to the patient and medical staff.

描述（由申请人提供）：我们已经产生了介入的心脏导管系统（SBDX），该系统提供了冠状动脉血管造影的70％的信噪比（SNR），仅15％的患者皮肤剂量，相对于常规系统。我们建议修改该系统，以15％的患者皮肤剂量提供100％的常规系统SNR。该荧光镜系统还具有独特的能力，可以在30帧/秒钟以3D定位容器和介入设备。我们建议利用这种能力来增强两种重要的临床程序的性能：冠状动脉血管成形术期间的准确气球和支架尺寸和使用射频（RF）导管消融的左心纤维化处理。 AIM 1- SNR的增加将通过构建相同设计的新检测器来实现，但面积更大2倍。我们将证明，通过比较图像质量指标以及SBDX和最先进的常规系统状态的猪成像研究的结果，我们已经实现了目标。 AIM 2-我们将证明SBDX在导管插入过程中执行精确的容器和装置尺寸的能力，以便它可以帮助干预主义者进行治疗。 AIM 3-我们将通过在手术过程中提供实时3D导管跟踪以及对CT和荧光镜图像的准确注册来证明SBDX在心脏结构定位方面的能力。心脏病是我们社会发病率和死亡率的重要原因。每年在我国每年进行500,000多种冠状动脉血管成形术和100,000 RF导管消融程序，挽救了许多生命并提高了更多的质量。这项研究的成功结果将提供治疗工具，从而改善这些程序的结果，同时大大降低对患者和医务人员的辐射暴露。