TUSCON EPIDEMIOLOGICAL STUDY OF AIRWAYS OBSTRUCTIVE DISEASE

气道阻塞性疾病的 TUSCON 流行病学研究

• 批准号: 3943115
• 负责人: BENJAMIN BURROWS
• 金额: --
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3943115
• 关键词: adolescence (12-20); aging; asthma; atopy; child physical development; disease /disorder proneness /risk; early diagnosis; emphysema; eosinophilia; health surveys; human middle age (35-64); human mortality; human population genetics; human subject; immunoglobulin E; longitudinal human study; methacholine; occupational disease /disorder; pollution related respiratory disorder; postmortem; pulmonary diffusion; questionnaires; residential mobility; respiratory airflow disorder; respiratory airflow measurement; respiratory airway pressure; respiratory airway volume; respiratory disorder epidemiology; respiratory infections; spirometry; young adult human (21-34)

This project represents a continuation of our major longitudinal study of a general population (The Tucson Epidemiological Study of Airways Obstructive Diseases). The sample was originally enrolled approximately 12 years ago, the ninth survey of the population has been recently completed. A very large and diverse data base has been accumulated on the greater than 1650 Tucson households containing greater than 4,000 subjects participating in the study. The major aims of this project continue to be the determination of the pathogeneses, natural histories, methods of early detection, and means of prevention of airways obstructive diseases (AOD). It is planned to complete the 15+ years of follow-up of the population which was envisioned in the initial study design within the new grant period, and to follow specific subgroups of special interest throughout the entire duration of the project. The study will continue to involve expertise from many disciplines including epidemiology, biostatistics, physiology, radiology, and clinical as well as basic immunology in order to provide a multi-disciplinary approach to the study of AOD. New analyses will emphasize the incidence of new symptoms, disease, functional impairment as well as mortality in relationship to initial characteristics of the subjects, host risk factors , exposure to provocative factors and changes in these exposures, and the course of findings early in the study. Newly developing clinically significant AOD cases will continue to be identified and studied in detail in collaboration with other SCOR projects. By determining the interactions of host and environmental factors in determinants of symptoms and physiological status over 15 years age segments beginning at birth, the data from this study will allow one to "piece together" the evolution of both persistant and reactive airways diseases from early childhood, demonstrating sequence of events finally leading to clinically significant AOD. The risk factors being studied include early childhood respiratory illnesses, evidences of atopic predisposition, signs and symptoms suggesting bronchial reactivity, protease inhibitor status, genetic background, gender and early exposure to potential bronchial irritants (such as passive smoking). Potential provocative agents which may interact including smoking, intercurrent respiratory infections, and exposure to environmental and occupational pollutants.

该项目代表了我们主要纵向项目的延续 一般人群研究（图森流行病学研究 气道阻塞性疾病）。 样本原本是 大约 12 年前登记的第九次调查 人口近期已完成。 一个非常大且 已积累超过1650个不同的数据库 图森家庭包含超过 4,000 名受试者 参与研究。 该项目的主要目标 继续确定发病机制，自然 病史、早期发现方法和预防手段 气道阻塞性疾病（AOD）。 计划完成 对人群进行了 15 年以上的跟踪调查 在新资助期内的初步研究设计中设想的， 并在整个过程中关注特别感兴趣的特定小组 项目的整个持续时间。 该研究将继续 涉及许多学科的专业知识，包括流行病学、 生物统计学、生理学、放射学、临床以及基础 免疫学，以提供多学科的方法 AOD的研究。 新的分析将强调 新的症状、疾病、功能障碍以及 死亡率与初始特征的关系 受试者、宿主危险因素、暴露于刺激因素以及 这些暴露的变化以及早期发现的过程 研究。 新开发的具有临床意义的 AOD 病例 将继续被识别和详细研究 与其他 SCOR 项目的合作。 通过确定 决定因素中宿主和环境因素的相互作用 15岁以上年龄段的症状和生理状态 从出生开始，这项研究的数据将允许人们 “拼凑”持久性和反应性的演变 从幼儿期开始的呼吸道疾病，展示了顺序 最终导致具有临床意义的 AOD 的事件。 风险 正在研究的因素包括幼儿呼吸 疾病、特应性倾向的证据、体征和症状 提示支气管反应性、蛋白酶抑制剂状态、遗传 背景、性别和早期暴露于潜在的支气管 刺激物（如被动吸烟）。 潜在的挑衅因素 可能相互作用的因素包括吸烟、并发呼吸道疾病 感染以及暴露于环境和职业 污染物。