TUCSON CHILDREN'S RESPIRATORY STUDY

图森儿童呼吸研究

• 批准号: 3843522
• 负责人: LYNN M TAUSSIG
• 金额: --
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843522
• 关键词: adolescence (12-20); aging; asthma; atopy; bronchodilators; child (0-11); chronic disease /disorder; circadian rhythms; disease /disorder proneness /risk; family genetics; human puberty; human subject; immunoglobulin A; immunoglobulin E; immunologic skin test; longitudinal human study; lung disorder; methacholine; passive smoking; questionnaires; respiratory airflow disorder; respiratory airflow measurement; respiratory disorder; respiratory disorder diagnosis; respiratory function; respiratory hypersensitivity; respiratory infections; sign /symptom; spirometry; tobacco abuse; young adult human (21-34)

The objectives of this project, The Children's Respiratory Study, are to investigate prospectively and longitudinally the relationships of a number of potential risk factors, including acute lower respiratory tract illnesses (LRIs) in childhood, to the development of subsequent chronic lung disorders. The specific aims of P3 are to: 1) assess the relationship of acute early childhood lower respiratory tract illnesses (LRIs) to the growth of lung function and the development of airway hyperreactivity and chronic obstructive airways disease during young adulthood; 2) elucidate the roles of atopy and pre-illness lung function in the development of acute LRIs, chronic respiratory symptoms, abnormal lung function, airway hyperreactivity and diagnoses; 3) study the interrelationships of genetic, immunologic, physiologic, environmental and infectious factors with the development of chronic respiratory symptoms, airway hyperreactivity and diagnoses; 4) assess the relationship of the initiation of smoking and passive smoke exposure to lung function, atopy, bronchial responsiveness, and pulmonary symptomatology and diagnoses. This study is being conducted on a population of 1246 children who were enrolled in the project at birth together with their families between 1980-1984 and who have been followed in depth since then. This renewal will focus on continued in-depth evaluation of changes in respiratory health in these children as they age. Baseline lung function, airway reactivity, immunologic status, atopic response, and smoke exposure will be assessed in the enrolled child. New studies proposed include a more detailed assessment of factors related to asthma and allergy. Components of reactivity will be assessed through bronchoprovocation with methacholine, diurnal variation in peak flows, and bronchodilation following administration with an inhaled bronchodilator. Data concerning the incidence and prevalence of symptoms of asthma and allergy in enrolled children will be related to similar symptoms in their parents and other family members using pedigree analyses. Finally, we will acquire and freeze blood future molecular genetic studies, as well as cellular immunologic studies. These studies will help us to determine prospectively and longitudinally the major factors relating to the development of chronic obstructive airways disease during childhood and young adult life, thereby allowing us to determine the best methods of preventing and/or treating such chronic diseases.

该项目的目标是儿童的呼吸研究，是 前瞻性和纵向研究一个数字的关系 潜在的危险因素，包括急性下呼吸道 童年时期的疾病（LRI），发展随后的慢性 肺部疾病。 P3的具体目的是：1）评估 急性幼儿期下呼吸道疾病的关系 （LRI）肺功能的生长和气道的发展 年轻人期间过度反应性和慢性阻塞性气道疾病 成年2）阐明特应性和肺前肺功能在 急性LRI，慢性呼吸症状，异常肺的发展 功能，气道高反应性和诊断； 3）研究 遗传，免疫学，生理，环境和环境的相互关系 感染因素随着慢性呼吸道症状的发展， 气道高反应性和诊断； 4）评估 吸烟和被动烟雾暴露于肺功能，特温， 支气管反应能力，肺症状和诊断。 这 正在对1246名入学的儿童进行研究 在1980年至1984年之间的出生项目中，与家人一起 从那以后一直深入遵守的人。 这种续约将重点介绍对变化的持续深入评估 这些儿童随着年龄的增长而呼吸健康。 基线肺功能， 气道反应性，免疫学状态，特应反应和烟雾暴露 将在注册儿童中进行评估。 提出的新研究包括 对与哮喘和过敏有关的因素进行更详细的评估。 反应性的组成部分将通过支气管理液和 甲基苯胺，峰流的昼夜变化和支气管扩张 用吸入支气管扩张剂进行给药。 有关的数据 哮喘和过敏的症状的发病率和患病率 孩子将与父母和其他其他症状有关 家庭成员使用谱系分析。 最后，我们将获得并 冻结血液未来的分子遗传研究以及细胞 免疫学研究。 这些研究将帮助我们确定 纵向与慢性发展有关的主要因素 童年和成年时期的阻塞性气道疾病，从而 允许我们确定预防和/或治疗的最佳方法 这种慢性疾病。