TUCSON EPIDEMIOLOGICAL STUDY OF AIRWAYS OBSTRUCTIVE DISEASE

图森气道阻塞性疾病流行病学研究

• 批准号: 3757783
• 负责人: MICHAEL D LEBOWITZ
• 金额: --
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3757783
• 关键词: acute bronchitis; adolescence (12-20); aging; asthma; atopy; child (0-11); data collection; disease /disorder proneness /risk; early diagnosis; emphysema; environment; eosinophilia; family genetics; gender difference; health surveys; human mortality; human old age (65+); human population genetics; human subject; immunoglobulin E; immunologic skin test; immunology; infant human (0-1 year); longitudinal human study; newborn human (0-6 weeks); pathologic process; respiratory airflow disorder; respiratory disorder epidemiology; respiratory function; respiratory hypersensitivity; sign /symptom; statistics /biometry; young adult human (21-34)

This project represents a completion of our major longitudinal study of a general population (The Tucson Epidemiological Study of Airways Obstructive Diseases). The sample was originally enrolled starting approximately 17-18 years ago, the eleventh survey of the population has been recently completed. A very large and diverse data base has been accumulated on the greater than 1650 Tucson households containing greater than 4,500 subjects participating in the study. The major aims of this project continue to be the determination of the pathogeneses, natural histories, methods of early detection, and means of prevention of airways obstructive diseases (AOD). Most of the work will be completed for the 20 years of follow-up of the population which was envisioned in the initial study design, it is planned to follow specific subgroups of special interest within the new grant period of this project. This emphasis reflects the findings: pre- asthmatic and asthmatic conditions need further study, as do other influences in infancy, childhood and adolescence. Further studies include completing immunological and physiological studies in those enrolled as infants during the study, and further genetic studies. The study will continue to involve expertise from many disciplines including epidemiology, biostatistics, physiology, immunology, and clinical science in order to provide a multi-disciplinary approach to the study of AOD. New analyses will be emphasized, it will evaluate the incidence of new symptoms, disease, and functional impairment as well as mortality in relationship to initial characteristics of the subjects, host risk factors, exposure to provocative factors and changes in these exposures, and the course of findings early in the study. Newly developing clinically significant AOD cases will continue to be identified and studied in detail in collaboration with P2 and other SCOR projects. By determining the interactions of host and environmental factors in determinants of symptoms and physiological status over 20 year age segments beginning at birth, the data from this study will allow one to "piece together" the evolution of both persistent and reactive airways diseases from early childhood, demonstrating sequence of events finally leading to clinically significant AOD. The risk factors being studied include early childhood respiratory illnesses, evidences of an atopic predisposition, signs and symptoms suggesting bronchial reactivity, protease inhibitor status, genetic background, gender, age, respiratory infections, and early exposure to potential bronchial irritants.

该项目代表了我们对以下领域的主要纵向研究的完成： 一般人群（图森气道阻塞流行病学研究 疾病）。 样本最初大约于 17-18 年开始登记 几年前，第十一次人口普查刚刚结束 完全的。 已经积累了非常庞大且多样化的数据库 超过 1650 个图森家庭，包含超过 4,500 名受试者 参与研究。 该项目的主要目标仍然是 发病机制、自然史、早期方法的确定 气道阻塞性疾病（AOD）的检测和预防方法。 大部分工作将在后续20年完成 最初研究设计中设想的人群，计划 关注新赠款中特别感兴趣的特定子群体 本项目期间。 这种强调反映了以下发现： 哮喘和哮喘病以及其他疾病都需要进一步研究 影响婴儿期、儿童期和青少年期。 进一步的研究包括 完成入组者的免疫学和生理学研究 研究期间的婴儿，以及进一步的遗传学研究。 该研究将 继续吸收包括流行病学在内的许多学科的专业知识， 生物统计学、生理学、免疫学和临床科学 为 AOD 的研究提供了一种多学科的方法。 新分析 将被强调，它将评估新症状的发生率， 疾病、功能障碍以及与相关的死亡率 受试者的初始特征、宿主危险因素、暴露于 这些暴露的挑衅因素和变化，以及过程 研究早期的发现。 新开发的具有临床意义的 AOD 将继续合作确定和详细研究案例 与 P2 和其他 SCOR 项目。 通过确定宿主的相互作用 和环境因素是症状和生理的决定因素 从出生开始的20岁以上年龄段的状态，数据来自于此 研究将允许人们“拼凑”两种持久性的进化 和儿童早期的反应性气道疾病，展示了顺序 最终导致具有临床意义的 AOD 的事件。 风险因素 正在研究的包括早期儿童呼吸系统疾病、 特应性倾向、体征和症状提示支气管 反应性、蛋白酶抑制剂状态、遗传背景、性别、年龄、 呼吸道感染，以及早期接触潜在的支气管 刺激物。