SCOR: CHRONIC DISEASES OF THE AIRWAYS

SCOR：慢性气道疾病

• 批准号: 3106342
• 负责人: BENJAMIN BURROWS
• 金额: $ 201.53万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1991-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106342
• 关键词: emphysema; human subject; longitudinal human study; passive smoking; respiratory airflow disorder; respiratory disorder epidemiology

The objectives of the Arizona SCOR are to determine the pathogeneses, natural histories, methods of early detection, and means of prevention of airways obstructive diseases (AOD). Eight closely related epidemiological, clinical, pathophysiologic, and experimental Projects, supported by six Cores, comprise a coordinated multidisciplinary program. Our ongoing longitudinal study of a general population sample including greater than 1650 households and greater than 4000 subjects will be continued to determine the overall evolution of AOD, to identify hosts factors and extrinsic risk factors for these diseases (including the interaction of immunological factors and bronchial irritants), and to evaluate methods for their early detection. New analyses are focused on the evolution of lung function over time, on the incidence of new disease, on the effects of changes in risk factors, and on detailed characterization of end point cases. An already enrolled and characterized population of greater than 1200 newborns will also continue to be followed in regard to the risk factors for and the consequences of lower respiratory tract illness in infancy. Extensive physiological and immunological studies of both enrolled children and their families are being carried when the children reach five years of age, allowing assessment of the effects of familial factors in both the children and their parents. Bronchial reactivity tests are included in these evaluations and in a new prospective study of middle aged males who are at the highest risk of developing new AOD. The methods necessary for evaluation of functional characteristics of infants and young children are being developed within the SCOR. To determine the acute immunologic changes induced by lower respiratory tract infections in infancy, a study of infants hospitalized with viral bronchiolitis is proposed, which the mechanisms of these acute changes and of their sequelae are being studied in a controlled animal model of viral bronchiolitis. The inheritance of bronchial hyperreactivity and the mechanisms underlying such hyperreactivity are being investigated in a rabbit model, and the apparently unique muscarinic receptors involved in regulating bronchomotor tone are being further investigated in the final project of the SCOR. Thus, the total program approaches the problem of AOD in a variety of complementary ways which bring together the expertise of many scientific disciplines.

亚利桑那州SCOR的目标是确定 病原体，自然历史，早期检测方法和 防止气道阻塞性疾病（AOD）的手段。 八个密切相关的流行病学，临床，病理生理学， 和六个核心支持的实验项目包括 协调的多学科计划。 我们正在进行的纵向 研究包括大于1650的一般人群样本 家庭和超过4000名受试者将继续进行 确定AOD的总体演变，以识别宿主的因素 以及这些疾病的外部风险因素（包括 免疫因素和支气管刺激物的相互作用）和 评估方法的早期检测。 新分析是 专注于随着时间的流逝的肺功能的演变 新疾病的发生率，对风险变化的影响 因素，以及终点案例的详细表征。 一个 已经入学和特征的人口大于 关于1200名新生儿也将继续遵循 下呼吸道的危险因素和后果 婴儿期。 广泛的生理和免疫学 对入学儿童及其家人的研究正在 孩子们五岁时携带 评估家族因素对两个孩子的影响 和他们的父母。 支气管反应性测试包括 这些评估以及对中年的新的前瞻性研究 有发展新AOD风险最高的男性。 这 评估功能特征所需的方法 在SCOR内正在发展婴儿和幼儿。 确定较低的急性免疫学变化 婴儿期的呼吸道感染，对婴儿的研究 提出了患有病毒性支气管炎的住院 这些急性变化及其后遗症的机制是 在病毒支气管炎的受控动物模型中进行了研究。 支气管高反应性和机制的遗传 在兔子中研究了这种高反应性 模型，以及涉及的明显独特的毒蕈碱受体 在调节支气管运动时，正在进一步研究 SCOR的最终项目。 因此，总计划 在各种补充中处理AOD的问题 将许多科学的专业知识汇集在一起​​的方式 学科。