SCOR--CHRONIC DISEASES OF THE AIRWAYS

SCOR--慢性气道疾病

• 批准号: 3106339
• 负责人: BENJAMIN BURROWS
• 金额: $ 252.44万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-12-01 至 1996-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106339
• 关键词: respiratory airflow disorder; respiratory disorder epidemiology; respiratory hypersensitivity

The overall objectives of the Arizona SCOR are to determine the pathogenesis, natural histories, methods of early detection, and possible means of prevention of airways obstructive diseases (AOD). Nine closely related epidemiological, physiological, and experimental projects, supported by four cores provide a coordinated multidisciplinary interdepartmental program. The data from our longitudinal study of a general population sample including >1700 households and >4500 subjects will continue to be analyzed to identify innate and extrinsic risk factors for the development and progression of AOD. Data will continue to be collected on selected subsets of this population to maximize follow-up, to answer specific hypotheses, or to carry out detailed studies of lung structure and function. The cohort of >1200 newborns and their families enrolled several years ago will continue to be followed to determine the importance of inherited characteristics and events in infancy (especially viral lower respiratory tract illnesses) in determining lung function, bronchial reactivity, and immunologic status later in life. Detailed studies of lung growth and respiratory physiology of infants and children will be continued. The effects of smoke exposure on the developing lung will be assessed in infants and in an animal model. An already enrolled population of middle aged working subjects and families with bronchial hyperresponsiveness (BHR) will continue to be studied, with an emphasis on relating BHR and other host factors to the development and progression of airways abnormalities. Our canine model of viral bronchiolitis will be expanded to determine how induced "allergy" influences the effects of the viral infection, especially in regard to BR and immunologic status. The basic mechanisms involved in BR will be studied in vivo in a rabbit model with many features of allergic asthma and in excised airway preparations. Since preliminary work suggests an important role of the parasympathetic system in regulating BR, a detailed study of muscarinic and NANC receptors in the lung is included as well as a project to study the electrophysiology of parasympathetic airway ganglia which may be important in modulating airway function.

亚利桑那州 SCOR 的总体目标是确定 发病机制、自然史、早期检测方法以及可能的 预防气道阻塞性疾病（AOD）的方法。 九严密 相关的流行病学、生理学和实验项目， 由四个核心支持提供协调的多学科 跨部门计划。 我们的纵向研究数据 一般人口样本包括 >1700 个家庭和 >4500 名受试者 将继续进行分析，以确定先天和外在的风险因素 AOD 的发展和进展。 数据将继续 收集该人群的选定子集，以最大限度地进行后续行动， 回答具体的假设，或对肺进行详细的研究 结构和功能。 超过 1200 名新生儿及其家人的队列 将继续跟踪几年前注册的情况，以确定 婴儿期遗传特征和事件的重要性（尤其是 病毒性下呼吸道疾病）以确定肺功能， 支气管反应性和晚年的免疫状态。 详细的 婴儿和儿童的肺部生长和呼吸生理学研究 将继续。 烟雾暴露对肺部发育的影响 将在婴儿和动物模型中进行评估。 已报名的 中年工作人群及支气管疾病家庭人群 将继续研究高反应性（BHR），重点是 将 BHR 和其他宿主因素与疾病的发展和进展联系起来 气道异常。 我们的犬病毒性细支气管炎模型将是 扩大以确定诱发的“过敏”如何影响 病毒感染，尤其是 BR 和免疫状态。 这 BR 涉及的基本机制将在兔子模型中进行体内研究 具有过敏性哮喘和切除气道制剂的许多特征。 由于初步研究表明副交感神经的重要作用 调节 BR 的系统，毒蕈碱和 NANC 受体的详细研究 包括在肺部以及研究电生理学的项目 副交感气道神经节的调节可能很重要 气道功能。