DEMOLITION AND ASTHMA IN CHICAGO PUBLIC HOUSING

芝加哥公共住房的拆除和哮喘

• 批准号: 6877031
• 负责人: SAMUEL DOREVITCH
• 金额: $ 12.82万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-02 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6877031
• 关键词: air sampling /monitoring; asthma; clinical research; disease /disorder etiology; disease /disorder proneness /risk; dust; endotoxins; environmental exposure; environmental stressor; enzyme linked immunosorbent assay; housing; human subject; inflammation; nitric oxide; particle; pollen; pollution related respiratory disorder; public health; pulmonary respiration; respiratory airflow measurement; respiratory disorder epidemiology; respiratory hypersensitivity; urban area

DESCRIPTION (provided by applicant) Candidate: The candidate is a physician with a background in emergency medicine, currently training in occupational and environmental medicine. In the short term the candidate will obtain mentored experience conducting field research and will develop expertise in environmental asthma. Additionally the candidate will become proficient in biostatistics and environmental science methodologies through formal course-work and through field experience. In the long term the candidate intends to become an independent researcher in environmental epidemiology and to collaborate with medical and public health colleagues to improve the health of the public by preventing harmful environmental exposures, and also to improve our understanding of the mechanisms of asthma. Environment: The proposed training and research will be done at the University of Illinois at Chicago School of Public Health. The mentor and co- mentor of the proposed project have substantial expertise in air pollution monitoring, bio-aerosol sampling and analysis, inner-city asthma, asthma panel studies, time series analysis, and time-space cluster analysis. All of these fields of knowledge are important in environmental asthma research. The Center for Environmental Epidemiology is a forum for developing a broad understanding of leading-edge research and controversies. The faculty, laboratories and computing facilities of the School of Public Health will be available to the candidate. The School of Public Health, the Division of Epidemiology and Biostatistics, and the Division of Environmental and Occupational Health Sciences actively support the development of the candidate as an independent researcher in environmental epidemiology. Research Project: Inner city residents living in public housing are at increased risk for asthma morbidity and mortality. Cities in the United States are demolishing public housing developments. This may increase local concentrations of airborne particulate matter. The impact of this on asthma severity has not been studied. The proposed project is a panel study that will evaluate the impact of housing demolition on asthma severity of nearby public housing residents. The exposure will be characterized by environmental sampling. Health effects studied will be asthma symptoms, peak expiratory flow rate, and exhaled nitric oxide, an indicator of pulmonary inflammation. In order to determine the health effects of the particulate matter exposure, potential confounders and effect modifiers such as ambient air pollutants, pollen counts, and meteorological factors will be considered in a time-series analysis.

描述（由申请人提供） 候选人：候选人是具有紧急情况背景的医生 医学，目前在职业和环境医学方面的培训。 在 短期候选人将获得指导的经验指导领域 研究并将发展环境哮喘的专业知识。 另外 候选人将精通生物统计学和环境科学 通过正式的课程工作和实地经验。 在 长期候选人打算成为独立研究员 环境流行病学并与医疗和公共卫生合作 同事通过预防有害来改善公众的健康 环境暴露，也可以提高我们对 哮喘的机制。 环境：拟议的培训和研究将在 伊利诺伊大学芝加哥公共卫生学院。 导师和共同 拟议项目的导师在空气污染方面具有丰富的专业知识 监测，生物 - 大赛抽样和分析，内城哮喘，哮喘小组 研究，时间序列分析和时间空间群集分析。 所有这些 知识领域在环境哮喘研究中很重要。 这 环境流行病学中心是一个开发广泛的论坛 了解领先的研究和争议。 教师， 公共卫生学院的实验室和计算设施将是 可用于候选人。 公共卫生学院，部门 流行病学和生物统计学，环境和 职业健康科学积极支持候选人的发展 作为环境流行病学的独立研究人员。 研究项目：居住在公共住房的内城居民在 增加哮喘发病率和死亡率的风险。 联合的城市 各州正在拆除公共住房发展。 这可能会增加本地 空气颗粒物的浓度。 这对哮喘的影响 严重程度尚未研究。 拟议的项目是一项小组研究， 将评估住房拆除对附近哮喘严重程度的影响 公共住房居民。 曝光将以环境为特征 采样。研究的健康效应将是哮喘症状，峰值呼气流量 速率和呼出的一氧化氮，这是肺部炎症的指标。 在 为了确定颗粒物暴露的健康影响， 潜在的混杂因素和效应修饰符，例如环境空气污染物， 花粉计数和气象因素将在时间序列中考虑 分析。