X-RAY DIFFRACTION EQUIPMENT

X射线衍射设备

• 批准号: 3520007
• 负责人: WILLIAM L DUAX
• 金额: $ 16.7万
• 依托单位: HAUPTMAN-WOODWARD MEDICAL RESEARCH INST
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-12-01 至 1988-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3520007
• 关键词: X ray crystallography; biomedical equipment purchase; chemical structure; chemical structure function; computers; photography; protein structure

The goal of this proposal is to upgrade the x-ray diffraction equipment in use in the Molecular Biophysics Department of The Medical Foundation of Buffalo. This equipment is shared.by a major user group of seven PHS funded and two non-PHS funded principal investigators, all members of the Molecular Biophysics Department. In total 16 professional crystallographers work on the projects involved. Upgrades for which funds are requested will provide us with a state-of-the-art facility consisting of three diffractometers, each fully equipped with accessories required for research efforts for which the instruments are designated, one rotating anode generator with cameras for protein data collection and two sealed tube generators equipped with four cameras for preliminary photographic work. Presently, many of the components of the equipment are antiquated or inadequate for the level of complexity of the experiments. This situation can be corrected by the replacement of the computers that control two diffractometers with a single microVAX II, refurbishing of the goniometers of these instruments, replacement of the x-ray generator for the third diffractometer with an ultra-stable solid state generator, construction of a highly stable low temperature device for high resolution work, purchase of a generator and two cameras for photographic work and of a reduced temperature device and V-shaped film cassettes for protein data collection.

该提案的目标是升级 X 射线衍射 分子生物物理学系使用的设备 布法罗医学基金会。 该设备由主要人员共享 由 7 个 PHS 资助的用户组和 2 个非 PHS 资助的委托人组成的用户组 研究人员，分子生物物理学系的所有成员。 共有 16 名专业晶体学家参与该项目 涉及。 需要资金的升级将为我们提供 拥有最先进的设施，包括三个 衍射仪，每台都配备了所需的配件 仪器指定用于的研究工作，一 带摄像头的旋转阳极发生器，用于收集蛋白质数据 和两个配备四个摄像头的密封管发生器 前期摄影工作。 目前，许多组件 的设备陈旧或不适合水平 实验的复杂性。 这种情况可以通过以下方式纠正 更换控制两个衍射仪的计算机 使用单个 microVAX II，翻新这些测角仪 仪器，更换第三个 X 射线发生器 具有超稳定固态发生器的衍射仪， 构建高稳定性低温装置 解决工作，购买发电机和两台摄像机 摄影作品以及降温装置和V形 用于蛋白质数据收集的胶片盒。