MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM

少数民族高中生研究学徒计划

• 批准号: 3512739
• 负责人: ALAN N TAYLOR
• 金额: $ 2.8万
• 依托单位: BAYLOR COLLEGE OF DENTISTRY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-03-01 至 1994-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3512739
• 关键词: minority institution research support; secondary schools

This proposal requests funding for replacement of a Varian XL- 200 NMR with a Varian VXR-300 superconducting high resolution FT NMR. This instrument would meet critical needs for walk-on 1H and 13C spectroscopy, broad-band capabilities, and 2D NMR. The major user group consists of faculty form the Department of Medicinal Chemistry and Chemistry. Dr. Cassady will elucidate the structures and study the chemistry and molecular pharmacology of bioactive natural products. Dr. Boger and Dr. Fuchs will study the total synthesis of complex natural products with antitumor and other biological activity. Dr. Byrn will examine the interaction of drugs with DNA and RNA templates. Dr. Chang will study the chemistry of alkylation of DNA in vitro and the chemistry of alkylated oligonucleotides. Dr. Schwab will explore the mechanism and stereochemistry of key enzymatic processes including metabolism of fatty acids and dehydration reactions.

该提案要求资金替换Varian XL- 200 NMR具有VARIAN VXR-300超导高分辨率 ft nmr。 该乐器将满足步行的关键需求 1H和13C光谱，宽带功能以及2D NMR。 主要用户组由教职员工组成 药物化学和化学。 卡萨迪博士将阐明 结构并研究化学和分子 生物活性天然产品的药理学。 博格博士和博士 Fuchs将研究复杂天然产物的总合成 具有抗肿瘤和其他生物活性。 拜恩·威尔博士 检查药物与DNA和RNA模板的相互作用。 Chand博士将研究体外DNA烷基化的化学 和烷基化寡核苷酸的化学。 Schwab博士Will 探索关键酶促的机制和立体化学 过程包括脂肪酸和脱水的代谢 反应。