BRAIN MECHANISMS, TIMING AND TEMPORAL MEMORY

大脑机制、时间和暂时记忆

基本信息

  • 批准号:
    3476862
  • 负责人:
  • 金额:
    $ 10.61万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1988
  • 资助国家:
    美国
  • 起止时间:
    1988-06-01 至 1993-05-31
  • 项目状态:
    已结题

项目摘要

The ability to remember and use information accurately is very important, and impairments of timing and temporal memory profoundly disrupt an individual's life. These observations motivate research to understand the brain mechanisms involved in normal memory processing, and the types of pathology that produce timing dysfunctions and amnesia. Previous work in rats, monkeys, and humans has demonstrated that lesions of frontal and temporal lobe structures, particularly the hippocampus and frontal cortex, produce behavioral changes that have some of the basic characteristics of an amnesic syndrome. The purpose of the present proposal is to apply a quantitative information processing model of timing behavior to data obtained in rats showing individual differences in the content of temporal memory. The nature of these individual differences in the content of temporal memory will be evaluated by examining a number of selected variables. The contribution of external influences, such as stimulus modality and stimulus intensity, on the content of temporal memory will be investigated in the first experimental module. In the second and third experimental modules, physiological activity of cholinergic neurons as measured by choline uptake in the hippocampus and frontal cortex and patterns of electrical activity as measured by theta rhythm in these same areas will be examined as possible indices of the magnitude and direction of temporal memory dysfunction. The fourth experimental module investigates the developmental contribution to alterations in the content of temporal memory. Here the effects of pre- and postnatal choline supplementation on the short-term facilitation of memory and the long-term protection against age-related changes in memory are evaluated. Together, these experiments help to determine the extent to which rats can be used as a model to investigate the brain mechanisms involved in timing and temporal memory dysfunctions that can be applied to other mammalian species.

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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WARREN H MECK其他文献

WARREN H MECK的其他文献

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{{ truncateString('WARREN H MECK', 18)}}的其他基金

PRENATAL CHOLINE AVAILABILITY: IMPACT ON AGE-RELATED DEFICITS IN SLEEP AND MEMORY
产前胆碱可用性:对年龄相关的睡眠和记忆力缺陷的影响
  • 批准号:
    6867650
  • 财政年份:
    2004
  • 资助金额:
    $ 10.61万
  • 项目类别:
PERINATAL CHOLINE AVAILABILITY, ATTENTION, AND AGING
围产期胆碱的可用性、注意力和衰老
  • 批准号:
    6299313
  • 财政年份:
    2000
  • 资助金额:
    $ 10.61万
  • 项目类别:
PERINATAL CHOLINE AVAILABILITY, ATTENTION, AND AGING
围产期胆碱的可用性、注意力和衰老
  • 批准号:
    6098291
  • 财政年份:
    1999
  • 资助金额:
    $ 10.61万
  • 项目类别:
PERINATAL CHOLINE SUPPLEMENTATION, MEMORY, AND AGING
围产期胆碱补充、记忆力和衰老
  • 批准号:
    6267501
  • 财政年份:
    1998
  • 资助金额:
    $ 10.61万
  • 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
  • 批准号:
    2034420
  • 财政年份:
    1997
  • 资助金额:
    $ 10.61万
  • 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
  • 批准号:
    2890721
  • 财政年份:
    1997
  • 资助金额:
    $ 10.61万
  • 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
  • 批准号:
    6186495
  • 财政年份:
    1997
  • 资助金额:
    $ 10.61万
  • 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
  • 批准号:
    2675386
  • 财政年份:
    1997
  • 资助金额:
    $ 10.61万
  • 项目类别:
PERINATAL CHOLINE SUPPLEMENTATION, MEMORY, AND AGING
围产期胆碱补充、记忆力和衰老
  • 批准号:
    6234273
  • 财政年份:
    1996
  • 资助金额:
    $ 10.61万
  • 项目类别:
BRAIN MECHANISMS, TIMING AND TEMPORAL MEMORY
大脑机制、时间和暂时记忆
  • 批准号:
    3476860
  • 财政年份:
    1988
  • 资助金额:
    $ 10.61万
  • 项目类别:

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  • 项目类别:
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大脑机制、时间和暂时记忆
  • 批准号:
    3476860
  • 财政年份:
    1988
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    $ 10.61万
  • 项目类别:
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  • 批准号:
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  • 财政年份:
    1988
  • 资助金额:
    $ 10.61万
  • 项目类别:
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大脑机制、时间和暂时记忆
  • 批准号:
    3476861
  • 财政年份:
    1988
  • 资助金额:
    $ 10.61万
  • 项目类别:
BRAIN MECHANISMS, TIMING AND TEMPORAL MEMORY
大脑机制、时间和暂时记忆
  • 批准号:
    3476859
  • 财政年份:
    1988
  • 资助金额:
    $ 10.61万
  • 项目类别:
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