BRAIN MECHANISMS, TIMING AND TEMPORAL MEMORY

大脑机制、时间和暂时记忆

• 批准号: 3476862
• 负责人: WARREN H MECK
• 金额: $ 10.61万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3476862
• 关键词: animal age group; brain electrical activity; brain metabolism; choline; frontal lobe /cortex; hippocampus; laboratory rat; memory; memory disorders; neural information processing; neurons; parasympathetic nervous system; psychological reinforcement; stimulus generalization

The ability to remember and use information accurately is very important, and impairments of timing and temporal memory profoundly disrupt an individual's life. These observations motivate research to understand the brain mechanisms involved in normal memory processing, and the types of pathology that produce timing dysfunctions and amnesia. Previous work in rats, monkeys, and humans has demonstrated that lesions of frontal and temporal lobe structures, particularly the hippocampus and frontal cortex, produce behavioral changes that have some of the basic characteristics of an amnesic syndrome. The purpose of the present proposal is to apply a quantitative information processing model of timing behavior to data obtained in rats showing individual differences in the content of temporal memory. The nature of these individual differences in the content of temporal memory will be evaluated by examining a number of selected variables. The contribution of external influences, such as stimulus modality and stimulus intensity, on the content of temporal memory will be investigated in the first experimental module. In the second and third experimental modules, physiological activity of cholinergic neurons as measured by choline uptake in the hippocampus and frontal cortex and patterns of electrical activity as measured by theta rhythm in these same areas will be examined as possible indices of the magnitude and direction of temporal memory dysfunction. The fourth experimental module investigates the developmental contribution to alterations in the content of temporal memory. Here the effects of pre- and postnatal choline supplementation on the short-term facilitation of memory and the long-term protection against age-related changes in memory are evaluated. Together, these experiments help to determine the extent to which rats can be used as a model to investigate the brain mechanisms involved in timing and temporal memory dysfunctions that can be applied to other mammalian species.

准确记住和使用信息的能力非常 重要的，以及时间和暂时记忆的障碍 破坏个人的生活。 这些观察激发了研究 了解正常记忆中涉及的大脑机制 处理以及产生时间的病理类型 功能障碍和健忘症。 以前在老鼠，猴子和 人类证明了额叶和颞叶的病变 结构，尤其是海马和额叶皮层， 产生具有一些基本的行为变化 健忘症综合征的特征。 现在的目的 建议是应用定量信息处理模型 在显示个体的大鼠中获得的数据的时序行为 时间内存内容的差异。 这些的本质 时间内存内容的个体差异将是 通过检查许多选定的变量来评估。 这 外部影响的贡献，例如刺激方式和 刺激强度，关于时间内存的内容 在第一个实验模块中进行了研究。 第二， 第三实验模块，胆碱能的生理活性 神经元通过海马中的胆碱摄取测量和 额叶皮质和电活动的模式，如 在这些相同领域的theta节奏将受到检查 时间内存的幅度和方向的指标 功能障碍。 第四个实验模块研究了 对改变内容的发展贡献 时间记忆。 在这里，产后和产后胆碱的作用 补充记忆的短期促进和 长期保护与年龄相关的记忆变化是 评估。 这些实验在一起有助于确定 大鼠可以用作研究的范围 涉及时间和时间记忆涉及的大脑机制 可以应用于其他哺乳动物物种的功能障碍。