BRAIN MECHANISMS, TIMING AND TEMPORAL MEMORY
大脑机制、时间和暂时记忆
基本信息
- 批准号:3476862
- 负责人:
- 金额:$ 10.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1988
- 资助国家:美国
- 起止时间:1988-06-01 至 1993-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The ability to remember and use information accurately is very
important, and impairments of timing and temporal memory profoundly
disrupt an individual's life. These observations motivate research
to understand the brain mechanisms involved in normal memory
processing, and the types of pathology that produce timing
dysfunctions and amnesia. Previous work in rats, monkeys, and
humans has demonstrated that lesions of frontal and temporal lobe
structures, particularly the hippocampus and frontal cortex,
produce behavioral changes that have some of the basic
characteristics of an amnesic syndrome. The purpose of the present
proposal is to apply a quantitative information processing model
of timing behavior to data obtained in rats showing individual
differences in the content of temporal memory. The nature of these
individual differences in the content of temporal memory will be
evaluated by examining a number of selected variables. The
contribution of external influences, such as stimulus modality and
stimulus intensity, on the content of temporal memory will be
investigated in the first experimental module. In the second and
third experimental modules, physiological activity of cholinergic
neurons as measured by choline uptake in the hippocampus and
frontal cortex and patterns of electrical activity as measured by
theta rhythm in these same areas will be examined as possible
indices of the magnitude and direction of temporal memory
dysfunction. The fourth experimental module investigates the
developmental contribution to alterations in the content of
temporal memory. Here the effects of pre- and postnatal choline
supplementation on the short-term facilitation of memory and the
long-term protection against age-related changes in memory are
evaluated. Together, these experiments help to determine the
extent to which rats can be used as a model to investigate the
brain mechanisms involved in timing and temporal memory
dysfunctions that can be applied to other mammalian species.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WARREN H MECK其他文献
WARREN H MECK的其他文献
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{{ truncateString('WARREN H MECK', 18)}}的其他基金
PRENATAL CHOLINE AVAILABILITY: IMPACT ON AGE-RELATED DEFICITS IN SLEEP AND MEMORY
产前胆碱可用性:对年龄相关的睡眠和记忆力缺陷的影响
- 批准号:
6867650 - 财政年份:2004
- 资助金额:
$ 10.61万 - 项目类别:
PERINATAL CHOLINE AVAILABILITY, ATTENTION, AND AGING
围产期胆碱的可用性、注意力和衰老
- 批准号:
6299313 - 财政年份:2000
- 资助金额:
$ 10.61万 - 项目类别:
PERINATAL CHOLINE AVAILABILITY, ATTENTION, AND AGING
围产期胆碱的可用性、注意力和衰老
- 批准号:
6098291 - 财政年份:1999
- 资助金额:
$ 10.61万 - 项目类别:
PERINATAL CHOLINE SUPPLEMENTATION, MEMORY, AND AGING
围产期胆碱补充、记忆力和衰老
- 批准号:
6267501 - 财政年份:1998
- 资助金额:
$ 10.61万 - 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
- 批准号:
2034420 - 财政年份:1997
- 资助金额:
$ 10.61万 - 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
- 批准号:
2890721 - 财政年份:1997
- 资助金额:
$ 10.61万 - 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
- 批准号:
6186495 - 财政年份:1997
- 资助金额:
$ 10.61万 - 项目类别:
FUNCTIONAL AND NEURAL MECHANISMS OF INTERVAL TIMING
间隔计时的功能和神经机制
- 批准号:
2675386 - 财政年份:1997
- 资助金额:
$ 10.61万 - 项目类别:
PERINATAL CHOLINE SUPPLEMENTATION, MEMORY, AND AGING
围产期胆碱补充、记忆力和衰老
- 批准号:
6234273 - 财政年份:1996
- 资助金额:
$ 10.61万 - 项目类别:
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