BRAIN MECHANISMS, TIMING AND TEMPORAL MEMORY

大脑机制、时间和暂时记忆

• 批准号: 3476861
• 负责人: WARREN H MECK
• 金额: $ 10.21万
• 依托单位: COLUMBIA UNIV NEW YORK MORNINGSIDE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-01 至 1993-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3476861
• 关键词: animal age group; brain electrical activity; brain metabolism; choline; frontal lobe /cortex; hippocampus; laboratory rat; memory; memory disorders; neural information processing; neurons; parasympathetic nervous system; psychological reinforcement; stimulus generalization

The ability to remember and use information accurately is very important, and impairments of timing and temporal memory profoundly disrupt an individual's life. These observations motivate research to understand the brain mechanisms involved in normal memory processing, and the types of pathology that produce timing dysfunctions and amnesia. Previous work in rats, monkeys, and humans has demonstrated that lesions of frontal and temporal lobe structures, particularly the hippocampus and frontal cortex, produce behavioral changes that have some of the basic characteristics of an amnesic syndrome. The purpose of the present proposal is to apply a quantitative information processing model of timing behavior to data obtained in rats showing individual differences in the content of temporal memory. The nature of these individual differences in the content of temporal memory will be evaluated by examining a number of selected variables. The contribution of external influences, such as stimulus modality and stimulus intensity, on the content of temporal memory will be investigated in the first experimental module. In the second and third experimental modules, physiological activity of cholinergic neurons as measured by choline uptake in the hippocampus and frontal cortex and patterns of electrical activity as measured by theta rhythm in these same areas will be examined as possible indices of the magnitude and direction of temporal memory dysfunction. The fourth experimental module investigates the developmental contribution to alterations in the content of temporal memory. Here the effects of pre- and postnatal choline supplementation on the short-term facilitation of memory and the long-term protection against age-related changes in memory are evaluated. Together, these experiments help to determine the extent to which rats can be used as a model to investigate the brain mechanisms involved in timing and temporal memory dysfunctions that can be applied to other mammalian species.

准确记忆和使用信息的能力非常重要 重要的是，时间和时间记忆的严重损害 扰乱一个人的生活。 这些观察激发了研究 了解正常记忆所涉及的大脑机制 处理，以及产生计时的病理类型 功能障碍和健忘症。 先前在大鼠、猴子和 人类已经证明额叶和颞叶的病变 结构，特别是海马体和额叶皮层， 产生具有一些基本特征的行为改变 遗忘综合症的特征。 目前的目的 建议是应用定量信息处理模型 大鼠的计时行为数据显示个体 时间记忆内容的差异。 这些的性质 时间记忆内容的个体差异 通过检查一些选定的变量进行评估。 这 外部影响的贡献，例如刺激方式和 刺激强度对时间记忆内容的影响 在第一个实验模块中进行了研究。 在第二个和 第三实验模块，胆碱能生理活性 通过海马体中胆碱的摄取来测量神经元和 额叶皮层和电活动模式通过测量 将尽可能检查这些相同区域的 theta 节律 时间记忆的大小和方向的指标 功能障碍。 第四个实验模块研究 发展对内容变化的贡献 暂时的记忆。 这是产前和产后胆碱的影响 补充短期记忆和 长期预防与年龄相关的记忆变化是 评价。 这些实验共同有助于确定 在多大程度上可以使用大鼠作为模型来研究 参与时间和时间记忆的大脑机制 可应用于其他哺乳动物物种的功能障碍。