PERINATAL CHOLINE SUPPLEMENTATION, MEMORY, AND AGING

围产期胆碱补充、记忆力和衰老

• 批准号: 6234273
• 负责人: WARREN H MECK
• 金额: $ 20.08万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6234273
• 关键词: age difference; aging; behavior modification; behavior test; behavioral /social science research tag; choline; developmental neurobiology; dietary supplements; laboratory rat; memory; molecular psychobiology; mother /embryo /fetus nutrition; nutrition related tag; perinatal; space perception; visual perception

The ability to remember and use information accurately is very important, and impairments of visuospatial memory profoundly disrupt and individual's life. These observations motivate research to understand the brain mechanisms involved in normal memory processing, and the types of lifespan developmental changes that produce memory dysfunctions and amnesia. At the same time it is of critical importance to understand the early developmental stages that brain and behavior processes go through in terms of defining memory function in later life. previous work in rats, monkeys, and humans has demonstrated that modification of frontal and temporal lobe structures, particularly the hippocampus and frontal cortex, produce behavioural changes that have some of the basic characteristics of an amnesic syndrome. The purpose of the present proposal is to investigate further our recent findings that indicate the potential for organization changes in these same structures that subserve visuospatial memory by exposing the developing nervous system to choline supplementation. Such perinatal choline supplementation has produced relatively permanent changes in the spatial ability of rats treated during specified periods (embryonic days 12-17 and postnatal days 15-30). The behavioral changes have been interpreted as reflecting an increase in memory capacity and precision. One of the major goals is to determine if there are any negative consequences of these treatments that might be revealed by the recruitment of normal aging processes. In this regard, we will investigate the three possibilities that perinatal choline supplementation either has a) a positive effect on the accuracy of visuospatial memory as a function of aging, b) a neutral effect on visuopatial memory as a function of aging. These behavioral data will stimulate additional studies of the anatomical and neurochemical basis of these effects.

准确记住和使用信息的能力非常重要， 视觉空间记忆的损害深刻破坏和 个人的生活。 这些观察激发了研究以了解 正常内存处理中涉及的大脑机制和类型 生命周期变化会导致记忆功能障碍和 健忘症。 同时，了解 大脑和行为过程经历的早期发育阶段 在以后的生活中定义记忆功能。 以前的工作 大鼠，猴子和人类已经证明了额叶的修饰 和颞叶结构，尤其是海马和额叶 皮质，产生具有一些基本的行为变化 健忘症综合征的特征。 现在的目的 提案是进一步调查我们最近的发现，这些发现表明 在这些相同结构中的组织变化的潜力 视觉空间记忆通过暴露于胆碱的发育中的神经系统 补充。 这种围产期胆碱补充已产生 治疗大鼠的空间能力的相对永久变化 在指定期间（胚胎天第12-17天和产后15-30天）。 行为变化已被解释为反映了增加 在记忆容量和精度中。 主要目标之一是确定 如果这些治疗可能有任何负面后果 通过募集正常衰老过程揭示。 在这方面， 我们将研究围产期胆碱的三种可能性 补充要么具有a）对准确性的积极影响 视觉空间记忆是衰老的函数，b）对 视觉记忆是衰老的函数。 这些行为数据将 刺激解剖学和神经化学基础的其他研究 这些效果。