Small Grant for Visiting Researcher Professor Marek Kimmel, Rice University

为莱斯大学客座研究员 Marek Kimmel 教授提供小额资助

• 批准号: EP/J006653/1
• 负责人: David Rand
• 金额: $ 3.05万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ006653%2F1
• 关键词: Small; Grant; Visiting; Researcher; Professor

Systems Biology (SB) seeks to understand the workings of biological systems as a whole, placing a greater emphasis on the interactions between components, and the consequences of such interactions, than on the molecular components themselves. As such mathematical modelling and statistical analysis are key theoretical tools. Such work is considered to be of great importance to a better understanding of an enormously broad range of biological and medical priorities such as disease mechanisms, pharmaceutical drug discovery, drug target validation, and horticulture and agriculture. Dr Kimmel is an internationally leading expert in three areas which are central to this research: branching processes (particularly theory and applications in cell biology and genetics); statistical aspects of genetics and genomics; and mathematical modelling of cellular signaling systems. This grant is to fund a visit of four and a half months to the University of Warwick to mutually strengthen research in these areas and to encourage new collaborations between researchers at Dr Kimmel's group, and researchers at Warwick and elsewhere with interests in Systems Biology or the mathematical/statistical skills to contribute to it.

系统生物学（SB）致力于理解生物系统作为一个整体的运作方式，更加强调组分之间的相互作用以及这种相互作用的后果，而不是分子组分本身。因此，数学建模和统计分析是关键的理论工具。此类工作被认为对于更好地理解广泛的生物和医学优先事项（例如疾病机制、药物发现、药物靶标验证以及园艺和农业）非常重要。 Kimmel 博士是本研究核心三个领域的国际领先专家：分支过程（特别是细胞生物学和遗传学的理论和应用）；遗传学和基因组学的统计方面；和细胞信号系统的数学建模。这笔赠款将资助对华威大学为期四个半月的访问，以相互加强这些领域的研究，并鼓励 Kimmel 博士小组的研究人员与华威大学和其他对系统生物学或系统生物学感兴趣的研究人员之间进行新的合作。数学/统计技能对此做出贡献。

项目成果

Modeling Neutral Evolution Using an Infinite-Allele Markov Branching Process

使用无限等位基因马尔可夫分支过程模拟中性进化

• DOI: http://dx.10.1155/2013/963831
• 发表时间: 2013
• 期刊: International Journal of Stochastic Analysis
• 作者: Wu X

Dynamic cross talk model of the epithelial innate immune response to double-stranded RNA stimulation: coordinated dynamics emerging from cell-level noise.

上皮先天免疫反应对双链 RNA 刺激的动态串扰模型：细胞级噪声中出现的协调动力学。

• DOI: http://dx.10.1371/journal.pone.0093396
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Bertolusso R

Temperature regulates NF-?B dynamics and function through timing of A20 transcription.

温度通过 A20 转录的时间调节 NF-κB 动力学和功能。

• DOI: http://dx.10.1073/pnas.1803609115
• 发表时间: 2018
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1
• 作者: Harper CV