Mobility Life: Monitoring Mobility in Daily Lives of People with Neurological Disease

移动生活：监测神经系统疾病患者日常生活中的移动能力

• 批准号: 9523322
• 负责人: Mahmoud El-Gohary
• 金额: $ 88.63万
• 依托单位: APDM, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-30 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9523322
• 关键词: Admission activity; Adult; Age; Algorithms; Ankle; Bandage; Businesses; Cessation of life; Clinic; Clinical; Clinical Research; Collaborations; Complex; Consensus; Databases; Disease Progression; Environment; Equilibrium; Fatigue; Gait; Goals; Grant; Health Sciences; Home environment; Hospitals; Human; Huntington Disease; Impairment; Injury; Laboratories; Length; Life; Measures; Medical; Mission; Monitor; Movement; Movement Disorders; Multiple Sclerosis; Neurologic; Neurologist; Neurology; Nursing Homes; Oregon; Parkinson Disease; Patient Monitoring; Patients; Performance; Pharmaceutical Preparations; Phase; Preparation; Quality of life; Reference Values; Reporting; Research Personnel; Severities; Shoes; Small Business Innovation Research Grant; Stress; System; Technology; Testing; Treatment Efficacy; Universities; Visiting Nurse; Wireless Technology; Work; age related; clinical practice; disability; experience; fall risk; falls; foot; improved; innovation; instrument; interest; intervention effect; light weight; mild cognitive impairment; nervous system disorder; novel; patient population; physical therapist; prospective; response; sensor; technology development; verification and validation; wearable technology

Project Summary Falls are the leading cause of injuries, hospital visits, nursing home admissions, and reduced quality of life for people with neurological disorders. Although there is consensus that impaired mobility is the basis for most falls, it is very difficult to evaluate these complex abilities outside a laboratory setting. Brief clinical examinations do not accurately reflect daily, functional mobility in real life environments. Patients at risk of falls would benefit from a system they can easily use to measure their daily mobility, assess mobility fluctuations throughout the day, evaluate their risk of falling, and measure effects of interventions aimed at improving their functional mobility and reducing their falls. No commercial technology yet exists to continuously monitor fluctuations in mobility or quantify fall risk in natural environments during normal activities. We developed and validated an unobtrusive system, called Mobility Life, to objectively characterize gait and turning during spontaneous activities with wearable inertial sensors. During this Phase II, we will develop an instrumented ankle wrap for continuous monitoring of gait, develop a user interface to support clinical research, develop reports that show indications of fall risk for clinical practice, and thoroughly verify and validate our technology. We will also determine which metrics are most indicative of fall risk and determine normative values for non-fallers in the same age range as the expected patient populations. Our specific aims are: AIM I. Technology Development: Prepare Mobility Life for clinical practice. · Milestone 1: Develop an instrumented elastic ankle bandage (SmartSox) for continuous gait monitoring. · Milestone 2: Develop useful clinical reports to convey patients' daily mobility impairments, fluctuations, and fall risk. · Milestone 3: Complete the system verification and validation in preparation for FDA 510(k) clearance to market. Aim II. Clinical Research: Demonstrate the clinical utility of Mobility Life to monitor quality of functional mobility and fall risk in neurological patients. · Milestone 4: Determine which daily life mobility impairments best predict fall risk in patients with PD or MS. · Milestone 5: Develop reference values for integrity of functional mobility in healthy age-matched subjects.

项目概要 跌倒是导致受伤、住院、入住疗养院以及生活质量下降的主要原因 尽管人们一致认为行动能力受损是大多数跌倒的原因， 在实验室环境之外评估这些复杂的能力是非常困难的。 不能准确反映现实生活环境中的日常功能活动性，有跌倒风险的患者将受益。 他们可以轻松地使用一个系统来测量他们的日常流动性，评估全天的流动通量， 评估他们跌倒的风险，并衡量旨在改善其功能活动能力的干预措施的效果 并减少他们的跌倒，目前还没有商业技术来连续监测流动性或流动性。 量化正常活动期间自然环境中的跌倒风险。 我们开发并验证了一个名为 Mobility Life 的不显眼的系统，可以客观地描述步态和 在第二阶段，我们将开发一个 用于持续监测步态的仪器化脚踝包裹，开发支持临床研究的用户界面， 制定显示临床实践跌倒风险迹象的报告，并彻底验证和验证我们的 我们还将确定哪些指标最能反映跌倒风险并确定规范值。 对于与预期患者群体相同年龄范围的非跌倒者，我们的具体目标是： 目标 I. 技术开发：为临床实践准备 Mobility Life。 · 里程碑 1：开发用于连续步态监测的仪器化弹性踝关节绷带 (SmartSox)。 · 里程碑 2：开发有用的临床报告，传达患者的日常活动障碍、影响和影响 跌倒风险。 · 里程碑 3：完成系统验证和确认，为 FDA 510(k) 许可做好准备 市场。 目标 II。临床研究：展示 Mobility Life 在监测质量方面的临床实用性 神经系统患者的功能活动能力和跌倒风险。 · 里程碑 4：确定哪些日常生活活动障碍最能预测帕金森病或帕金森病患者的跌倒风险 多发性硬化症。 · 里程碑 5：为健康年龄匹配受试者的功能活动完整性制定参考值。

项目成果

Laboratory versus daily life gait characteristics in patients with multiple sclerosis, Parkinson's disease, and matched controls.

多发性硬化症、帕金森病患者和匹配对照患者的实验室步态特征与日常生活步态特征的比较。

• 发表时间: 2020-12-01
• 作者: Shah, Vrutangkumar V;McNames, James;Mancini, Martina;Carlson;Spain, Rebecca I;Nutt, John G;El;Curtze, Carolin;Horak, Fay B
• 通讯作者: Horak, Fay B

Does gait bout definition influence the ability to discriminate gait quality between people with and without multiple sclerosis during daily life?

步态定义是否会影响日常生活中区分多发性硬化症患者和非多发性硬化症患者步态质量的能力？

• 发表时间: 2021
• 影响因子: 2.4
• 作者: Shah, Vrutangkumar V;McNames, James;Harker, Graham;Curtze, Carolin;Carlson;Spain, Rebecca I;El;Mancini, Martina;Horak, Fay B
• 通讯作者: Horak, Fay B